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이식후 발생한 IgA신병증에서 영상분석검사를 이용한 사구체 변화

Title
이식후 발생한 IgA신병증에서 영상분석검사를 이용한 사구체 변화
Other Titles
Image Analysis of Glomerular Changes in Patients with Post-transplant IgA Nephropathy
Authors
권계원;정현주
Issue Date
2001
Journal Title
Korean Journal of Pathology (대한병리학회지)
ISSN
0379-1149
Citation
Korean Journal of Pathology (대한병리학회지), Vol.35(3) : 206~211, 2001
Abstract
Background: IgA nephropathy after renal transplantation (post-transplant IgAN) may recapitulate the IgAN of native kidneys, however, little has been reported about the histologic characteristics. The aim of this study is to apply glomerular morphometry using an image analyser to examine the histologic characteristics of post-transplant IgAN. Methods: The outer margin of the glomerulus (Bowman’s area, BA) and glomerular tuft area (GA) were traced manually. The measured area were automatically calculated by KS300 image analysis system (Kontron, Munchen, Germany). The mesangial area (MA) was calculated with a summing each manually traced mesangial area. The total number of glomerular (GC) and mesangial cells (MC) were counted. Eight cases of renal section obtained by nephrectomy due to renal cell carcinoma (normal control: N-CTRL) and nineteen cases of renal section obtained from post-transplantation patients without IgAN (transplantation control: Tx-CTRL) served as controls. Results: A total of 35 biopsies were finally selected for measurement. BA and GA of post-transplant IgAN were 1.6 and 1.4 times larger than the N-CTRL, respectively, and were not significantly different from Tx-CTRL. MA was 1.4 times significantly larger than that of the Tx-CTRL. As compared to that of the N-CTRL, it was 1.2 times larger, but this difference was not statistically significant. The GC and MC of post-transplant IgAN and the Tx-CTRL were significantly lower than the N-CTRL. There were no significant correlations between glomerular hypertrophy and duration after renal transplantation, mesangial changes, segmental sclerosis, or degree of renal cortical interstitial fibrosis in post-transplant IgAN. Conclusions: Prominent glomerular hypertrophy and mesangial expansion suggest a hyperfiltration injury in post-transplant IgAN and a possible way to glomerulosclerosis.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142387
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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