섬유소원, 응고인자 VII 및 플라스미노겐 활성억제인자- 1의 유전자다형성과 관상동맥질환 위험인자 분석

Abstract

Objective: The aims of this study were to investigate the extent to which specific known polymorphisms of fibrinogen, factor Ⅶ (FⅦ) and PAI-1 genes are associated with their respective plasma levels. And also we examined whether these genotypes were linked to coronary artery disease (CAD).

Methods:We performed a case-control study of 165 patients which included 156 CAD and 9 peripheral artery obstructive disease and 188 healthy controls without a history of cardiovascular disease. The four polymorphisms of fibrinogen (β-455G/A, β448Arg/Lys), FⅦ (353Arg/Gln) and PAI-1 (4G/5G) gene were measured, together with their plasma levels.

Results: There was a difference between patients and controls in the frequency of the fibrinogen β448Lys allele (0.206 vs 0.106, P<0.001), but there were no significant frequency differences in fibrinogen β-455A (0.537 vs differences in fibrinogen β-455A (0.537 vs 0.529), FⅦ 353Gln (0.079 vs 0.080) and PAI-1 4G (0.146 vs 0.113) Allele. Plasma fibrinogen level was higher in patients (372.8±112.0㎎/㎗) than in controls (300.4±70.9㎎/㎗) and patients with genotype β448LysLys (457.8±134.4㎎/㎗) or β448ArgLys (397.3±120.8㎎/㎗) had higher fibrinogen levels than those with β488ArgArg (354.9±102.3㎎/㎗). Using multivariate logistic regression, the β448 ArgLys or LysLys genotype was associated with over twice the risk of CAD (odds ratio 2.25) compared with the β488ArgArg genotype. Hypertension is more potent risk factor for the person who has the β488Lys allele of fibrinogen.

Conclusions: These data provide evidence that a polymorphism of the fibrinogen β488Arg/Lys is associated with an increased risk of CAD and that hypertension is more potent risk factor for CAD in person who have the β488Lys allele of fibrinogen.