Cited 6 times in
The apolipoprotein(a) size, pentanucleotide repeat, C/T(+93) polymorphisms of apolipoprotein(a) gene, serum lipoprotein(a) concentrations and their relationship in a Korean population
DC Field | Value | Language |
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dc.contributor.author | 김정호 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최규옥 | - |
dc.date.accessioned | 2016-02-19T11:02:35Z | - |
dc.date.available | 2016-02-19T11:02:35Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 0009-8981 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/142266 | - |
dc.description.abstract | BACKGROUND: In addition to apolipoprotein(a) [apo(a)] kringle 4 variable number of tandem repeat (K4-VNTR), pentanucleotide repeat polymorphism (PNRP) and C/T(+93) polymorphism [C/T(+93)] of apo(a) gene have been suggested to be related to lipoprotein(a) [Lp(a)] concentration. We studied the distribution of these genetic polymorphisms and their relationship with Lp(a) concentrations in a Korean population. METHODS: One hundred thirty-two Korean adults were examined. Lp(a) was measured with enzyme-linked immunosorbent assay (ELISA). Apo(a) K4-VNTR was measured by high-resolution SDS-agarose gel separation and ECL Western blotting method. PNRP was measured after DNA amplification. The C/T(+93) ratio was measured by a amplification refractory mutation system. RESULTS: Lp(a) was inversely correlated with K4-VNTR (r=0.732, p<0.0001), but was associated neither with any PNRP haplotype nor with C/T(+93) by multiple regression analysis, although we found a significant decrease of Lp(a) in PNRP 9/9 individuals (p<0.01). There was a strong linkage disequilibrium between 9 haplotypes of PNRP and the T haplotype of C/T(+93). CONCLUSIONS: Inverse relationship between serum Lp(a) and K4 number of apo(a) was confirmed in normal Korean adults. PNRP 9/9 genotype appeared to have a reducing effect on Lp(a), but neither 9 haplotype heterozygotes of PNRP nor the T haplotype C/T(+93) affected Lp(a) concentrations in Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 113~123 | - |
dc.relation.isPartOf | CLINICA CHIMICA ACTA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apolipoproteins A/genetics* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Lipoprotein(a)/genetics* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Polymorphism, Genetic/genetics* | - |
dc.subject.MESH | Regression Analysis | - |
dc.title | The apolipoprotein(a) size, pentanucleotide repeat, C/T(+93) polymorphisms of apolipoprotein(a) gene, serum lipoprotein(a) concentrations and their relationship in a Korean population | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Laboratory Medicine (진단검사의학) | - |
dc.contributor.googleauthor | Jeong-Ho Kim | - |
dc.contributor.googleauthor | Kyung Ho Roh | - |
dc.contributor.googleauthor | Sang Min Nam | - |
dc.contributor.googleauthor | Hyun-Young Park | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Dong Kee Kim | - |
dc.contributor.googleauthor | Kyung Soon Song | - |
dc.identifier.doi | 10.1016/S0009-8981(01)00683-0 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00903 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04042 | - |
dc.relation.journalcode | J00543 | - |
dc.identifier.eissn | 1873-3492 | - |
dc.identifier.pmid | 11718686 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009898101006830?np=y | - |
dc.subject.keyword | Apolipoprotein(a) | - |
dc.subject.keyword | Lipoprotein(a) | - |
dc.subject.keyword | C/T polymorphism | - |
dc.subject.keyword | Kringle 4 variable number of tandem repeat | - |
dc.subject.keyword | Pentanucleotide repeat polymorphism | - |
dc.contributor.alternativeName | Kim, Jeong Ho | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choe, Kyu Ok | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Ho | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choe, Kyu Ok | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 314 | - |
dc.citation.number | 1-2 | - |
dc.citation.startPage | 113 | - |
dc.citation.endPage | 123 | - |
dc.identifier.bibliographicCitation | CLINICA CHIMICA ACTA, Vol.314(1-2) : 113-123, 2001 | - |
dc.identifier.rimsid | 31732 | - |
dc.type.rims | ART | - |
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