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삼출성 중이염에서 삼출액의 점도에 따른 조성의 차이

Other Titles
 Compositional Difference of Middle Ear Effusion according to Viscosity of the Effusion 
Authors
 윤주헌 ; 정명현 
Citation
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery (대한이비인후과학회지 두경부외과학), Vol.44(2) : 124~128, 2001 
Journal Title
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery (대한이비인후과학회지 두경부외과학) 
ISSN
 1225-035X 
Issue Date
2001
Abstract
Background and Objectives : Serous otitis media (SOM) is usually responsive to medical treatment, whereas mucoid otitis media (MOM) is not This study was undertaken to elucidate the compositional difference between serous and mucoid effusion, and to investigate whether MUC5AC acts as a major mucin in the middle ear mucosa with MOM. Materials and Methods : Middle ear effusion (MEE) samples were collected from 29 patients with MOM and 20 patients with SOM. The level of mucin, lysozyme, secretory IgA and interleukin-8 were measured by dot blotting or enzyme-linked immunosorbent assay. Periodic acid-Schiff and immunohistochemical staining with monoclonal anti-MUC5AC antibody were performed on the serial sections of middle ear mucosa with MOM. Results : Mucoid effusions contained higher levels of mucin, lysozyme, secretory IgA and interleukin-8 than serous effusion. Immunohistological study revealed that MUC5AC mucin was expressed in only a small portion of the goblet cells of middle ear mucosa with MOM. Conclusion : Our study suggests that both serous secretions and mucin might make the middle ear effusion more viscous, and that mucins other than MUC5AC might have a major role in the viscosity of MEE. Further study is necessary to identify the major mucins in the MEE of otitis media with effusion.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142212
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
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