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뇌종양에 의한 신경세포의 세포고사

Title
뇌종양에 의한 신경세포의 세포고사
Other Titles
Apoptosis of Surrounding Neurons by Brain tumor
Authors
김주항;김옥준;최일생;이병인;김태승;손정원;김세종;최인홍
Issue Date
2001
Journal Title
Journal of the Korean Neurological Association (대한신경과학회지)
ISSN
1225-7004
Citation
Journal of the Korean Neurological Association (대한신경과학회지), Vol.19(3) : 266~277, 2001
Abstract
Background: As brain tumor cells are immunologically active, they release various factors like a cytokine, growth factor and express a death domain on their surfaces. Accordingly they support proliferation, vascularity, invasiveness and maintain immune privileged sites. However, the relationship between tumor cells and surrounding neuron cells have been rarely reported in tumor patients with epilepsy that inhibitory neuron cells have been lost around peritumoral sites. This study was designed to address that tumor cells directly damage neuron cells. Methods: Using LDH assay and special stain, we investigated whether or not cultured supernatants of astrocytoma cells induce the damage of neuron cells. Results: The neuron cells were killed by tumor cells supernatant and increased by pretreatment of neuron cells super-natant and lysates. Protein extracted tumor cells supernatant also damage neuron cells. It was proved by Annexin-PI stain and DNA fragmentation that neuronal death by tumor cells was apoptosis. The more malignant tumor cells, the more neuronal death was induced and the more their cytokines were expressed. In comparison with various cytokine expres-sions in tumor cells, it can be assumed that the released protein from tumor cells was associated with TNF (tumor necro-sis factor)-α. Conclusions: Brain tumor cells are active processing cells that they recognize surrounding normal neuron cells, release death factors and induce apoptosis of neuron cells. Released death factors are related toTNF-α.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142210
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Neurology
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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