Age-Specific Reference Ranges for Serum Prostate-Specific Antigen: Community-based Survey in Namhae Region
Korean Journal of Urology (대한비뇨기과학회지)
Korean Journal of Urology (대한비뇨기과학회지), Vol.42(8) : 834~839, 2001
Purpose: To establish the relationship between serum prostate specific antigen (PSA) concentration and age in a community-based population without clinically evident prostate cancer, a population based screening study was performed in a rural area in Southern Korea.Materials and Methods: From January 1999 to December 1999, 1,278 volunteer men aged from 40 to 89 years in Namhae, Korea participated in a clinical examination that included a serum PSA determination (TANDEM-R assay), digital rectal examination and transrectal ultrasonography. The subjects who had clinical evidence of prostate cancer and high PSA concentration (＞10ng/ml) were excluded. The PSA levels were compared with age using Pearson correlation and linear regression analysis.Results: The serum PSA concentration correlated with patient age (r=0.129, p=0.001). The observed 95th percentile increased from 1.37ng/ml for subjects in the 40`s to 6.18ng/ml for subjects in the 80'2. The reference range for serum PSA (95 percentile) for men in the 40’s was 0.24 to 1.37ng/ml; for 50 to 59 years, 0.27 to 2.68ng/ml; for 60 to 69 years, 0.25 to 4.00ng/ml; for 70 to 79 years, 0.29 to 4.55ng/ml; and for 80 to 89 years, 0.31 to 6.18ng/ml.Conclusions: Our data showed that the serum PSA concentration directly correlated with patient age (Pearson correlation coefficient=0.129, P=0.001). Thus, rather than relying on a single reference range regardless of different age groups, it may be more appropriate to have age-specific reference ranges. Our data were lower than that of the Western data, and could provide an adjunctive information in interpreting PSA data in Korean men, especially in the elderly population.