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인슐린 저항성과 고감도 C-반응성단백의 연관성

 인슐린 저항성과 고감도 C-반응성단백의 연관성 
Other Titles
 The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein. 
 박노진 ; 김정호 ; 허갑범 ; 권오헌 ; 송경순 ; 김경래 ; 송영득 ; 윤용석 
Issue Date
Journal Title
 Korean Journal of Clinical Pathology (대한임상병리학회지) 
 Korean Journal of Clinical Pathology (대한임상병리학회지), Vol.21(6) : 465~470, 2001 
Background Insulin resistance is known as the common denominator of risk factors of atherosclerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans. Methods Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP. Results The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8±1.7) showed significantly decreased value compared with normal (8.4±1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. Conclusion There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.
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1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
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