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자궁경부임신에서 methotrexate치료법의 실패에 대한 예측 인자

Title
 자궁경부임신에서 methotrexate치료법의 실패에 대한 예측 인자
Other Titles
 Predictive factors for failure of methorexate treatment of cervical pregnancy
Authors
 이재성; 권자영; 이경주; 배상욱; 김정연; 장진범; 임재학; 안은희
Issue Date
2001
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지)
ISSN
 0494-4755
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.44(1) : 134~138, 2001
Abstract
Objective : The use of methotrexate for the treatment of cervical pregnancy is now common practice. Our study was performed to determine the risk factors when the primary methotrexate treatment of cervical pregnancy was failed. Methods : From January 1985 to December 1999, we studied 32 women with cervical pregnancies who were treated with methotrexate intramuscularly according to a repeated intramuscular injections protocol. For evaluation of the efficacy of therapy, pretreatment serum concentrations of human chorionic gonadotropin, the size of the gestational mass, fetal cardiac activity, and the presence of fluid in the peritoneal cavity were measured. This findings were analyzed and compared by means of the chi-square test, Fisher exact test, and student's t-test between the success and failure. Results : There was no relation between the women's age, parity, the size of the conceptus, or the presence of fluid in the peritoneal cavity and the efficacy of treatment. A cervical pregnancy that presented with a serum human chorionic gonadotropin concentration of ≥ 10,000mIU/ml, fetal cardiac activity was considered to be associated with a higher failure rate of primary methotrexate treatment. Conclusion : Among cervical pregnancies, a high serum human chorionic gonadotropin concentration and fetal cardiac activity were the important factors associated with failure of treatment with methotrexate.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142056
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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