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임신 제2분기 후 자궁동맥 도플러 파형 분석 상 함요를 이용한 임신성 고혈압 및 태아발육지연 예측

Other Titles
 The Prediction of Pre-eclampsia/Fetal Growth Restriction based on Notch of Uterine Artery Doppler Velocimetry 
Authors
 권혜경 ; 김영한 ; 박용원 ; 조재성 ; 김태윤 ; 이재성 ; 이창희 
Citation
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지), Vol.44(3) : 486~491, 2001 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회지) 
ISSN
 0494-4755 
Issue Date
2001
Abstract
Objectives : The objective of this study is to evaluate the predictability of pre-eclampsia and fetal growth restriction(FGR) using the notch of uterine artery Doppler velocimetry after the second trimester of pregnancy, and to evaluate the hemodynamic changes preceeding the onset of symptoms of pre-eclampsia, therefore determining the significance of the notch in uterine artery Doppler velocimetry. Materials and methods : Between March 1996 and April 1999, in Severance Hospital, 99 pregnant women who showed notches in uterine artery Doppler velocimetry at the 24th to 32nd gestational weeks were studied. Those already manifested by pre-eclampsia and FGR were excluded. The study population were divided into two groups, women in their 24-26th gestational weeks and in their 27-32nd gestational weeks, and the prevalence of pre-eclampsia and FGR were evaluated in each group. Also, the prevalence of the mentioned diseases according to the bilaterality of the notch, and the duration to the onset of the symptoms of pre-eclampsia were compared. Results : Among 42 patients who showed the notch in the 24-26th gestational weeks, 14 developed pre-eclampsia/FGR(33.3%), and among 57 in the 27-32nd gestational weeks, 17 developed the mentioned diseases(31.5%). No significant difference in prevalence rate was observed. In those who showed bilateral notches, 11 out of 24 cases developed pre-eclampsia/FGR(45.8%). In those with unilateral notch, 20 out of 75 cases had the disease(26.7%). The difference in the two groups were statistically significant(p<0.05). Among 42 patients who showed the notch in the 24-26th gestational weeks, 7 developed pre-eclampsia(16.7%), and among 57 in the 27-32nd gestational weeks, 17 developed pre-eclampsia(15.7%). No significant statistic difference was observed. The duration to the onset of symtoms of pre-eclampsia were 5.3 and 5.5 weeks each group. Conclusion : The notch means early marker of hemodynamic changes preceeding the onset of symptoms of pre-eclampsia. Therefore, patients who show the notch of uterine artery Doppler velocimetry in the second half of pregnancy should be considered as high risk patients for either pre-eclampsia or FGR, and especially those with bilateral notches require close observation and follow-up.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/142048
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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