Cited 0 times in

사람 정상 코점막 상피세포에서 사이토카인에 의한 MUC8과 MUC5AC의 발현 및 조절

Title
사람 정상 코점막 상피세포에서 사이토카인에 의한 MUC8과 MUC5AC의 발현 및 조절
Other Titles
Expression and regulation of MUC8 & MUC5AC by various cytokines in normal human nasal epithelial cells
Authors
이정권;문형진;윤주헌;김창우;김성식
Issue Date
2001
Journal Title
Korean Journal of Otorhinolaryngology-Head and Neck Surgery (대한이비인후과학회지 두경부외과학)
ISSN
1225-035X
Citation
Korean Journal of Otorhinolaryngology-Head and Neck Surgery (대한이비인후과학회지 두경부외과학), Vol.44(6) : 600~605, 2001
Abstract
Background and Objectives : Sinusitis is one of the most commonly reported diseases in the world. A network of inflammatory mediators is known to be involved in the pathogenesis of chronic sinusitis and nasal mucus secretion may also be under the control of an inflammatory mediator network. To date, 12 human mucin genes have been identified; however, the regulation of MUC8 has not yet been found out. In this study, we described the regulation of the MUC8 mRNA expression by inflammatory mediators and investigated its cellular location. Materials and Method : MUC8 mRNA and MUC5AC mRNA were detected in culture using passage-2 normal human nasal epithelial(NHNE) cells after the treatment with a mixture of following inflammatory mediators; TNF-α, IL-1β, LPS, IL-4, PAF. The translocation of MUC8 mRNA from the nucleus to the cytoplasm was investigated by treating the inflammatory mediators with in situ hybridization. Results : We found that a mixture of inflammatory mediators increased the MUC8 mRNA expression but decreased the MUC5AC mRNA expression in cultured normal human nasal epithelial cells. Among the inflammatory mediators, Interleukin-4 was responsible for the decrease in the MUC5AC mRNA expression and the MUC5AC mucin secretion. We also found that MUC8 mRNA resides in the nucleus of goblet cells and is transported into the cytoplasm following the treatment with inflammatory mediators. Conclusion : These results indicate that MUC8 may play an important role in the pathogenesis of mucus hypersecretion in chronic sinusitis.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/142028
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Otorhinolaryngology
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T200101453.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse