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Selection of a mobilization regimen for multiple myeloma based on the response to induction therapy: granulocyte-colony stimulating factor (G-CSF) alone versus high-dose cyclophosphamide plus G-CSF

Title
 Selection of a mobilization regimen for multiple myeloma based on the response to induction therapy: granulocyte-colony stimulating factor (G-CSF) alone versus high-dose cyclophosphamide plus G-CSF
Authors
 Ji Eun Jang; June-Won Cheong; Jin Seok Kim; Joon Seong Park; Jae Hoon Lee; Chang-Ki Min; Won-Sik Lee; Ho-Young Yhim; Hyeon-Seok Eom; Hyewon Lee; Cheolwon Suh; Hyunsoo Cho; Soo-Jeong Kim
Issue Date
2015
Journal Title
 Leukemia & Lymphoma
ISSN
 1042-8194
Citation
 Leukemia & Lymphoma, Vol.null(null) : null, 2015
Abstract
To evaluate the feasibility of selecting a mobilization regimen based on the response to induction therapy, we retrospectively analyzed 179 multiple myeloma patients who underwent stem cell mobilization. In comparison with patients who achieved at least a very good partial response (VGPR) to induction therapy and received granulocyte-colony stimulating factor (G-CSF) alone and patients who did not achieve a VGPR and received cyclophosphamide (CY) + G-CSF, treatment-related toxicity was greater and neutrophil engraftment was slower in the CY than the G-CSF group. The rate of requisite mobilization (≥ 2.0 × 106/kg) was similar in both groups. Overall and progression-free survival was not different between patients in the G-CSF group and patients who achieved at least VGPR and received CY + G-CSF. In conclusion, response-adapted selection of a mobilization regimen is appropriate. G-CSF alone should be the preferred treatment for patients who achieved at least a VGPR to induction therapy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141836
DOI
10.3109/10428194.2015.1102240
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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Link
 http://www.tandfonline.com/doi/full/10.3109/10428194.2015.1102240
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