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PTEN Methylation Dependent Sinonasal Mucosal Melanoma

Title
PTEN Methylation Dependent Sinonasal Mucosal Melanoma
Authors
Sang Hee Lee;Mi Ryung Roh;Sun Young Rha;Sang Eun Lee;Soo Hee Kim;Kyu Hyun Park;Beodeul Kang
Issue Date
2015
Journal Title
Cancer Research and Treatment
ISSN
1598-2998
Citation
Cancer Research and Treatment, Vol.null(null) : null, 2015
Abstract
Sinonasal mucosal melanoma (SMM) is an aggressive and rare type of melanoma. Although the classic RAS-RAF-MEK pathway is thought to be the main pathway involved in melanoma pathogenesis, genetic alterations in the PI3K-AKT pathway, including PTEN-regulated signaling, are also thought to contribute. So far, data regarding altered PTEN expression and epigenetic mechanism of PTEN silencing in development of SMM is extremely limited. Herein we report on a case of SMM with liver and bone metastases with an epigenetic alteration of PTEN. Results of mutation analysis for BRAF, NRAS, HRAS, KRAS, PIK3CA, C-kit, and PTEN were negative, however, methylation of PTEN CpG islands was observed. Our case not only supports PTEN as a major tumor suppressor involved in melanoma tumorigenesis, but also a potential epigenetic mechanism of PTEN silencing in development of SMM.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141802
DOI
10.4143/crt.2014.356
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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