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Validating of the pre-clinical mouse model for metastatic breast cancer to the mandible

Authors
 Young Sun HWANG ; Sang-Sun HAN ; Won-Yoon CHUNG ; Kwang-Kyun PARK ; Sun-Kyung LEE ; Ye-Jin LEE ; Ki-Rim KIM 
Citation
 Journal of Applied Oral Science, Vol.23(1) : 3~8, 2015 
Journal Title
 Journal of Applied Oral Science 
ISSN
 1678-7757 
Issue Date
2015
Abstract
Metastatic breast carcinoma has a great tendency to spread to the mandible. It is concomitantly associated with bone destruction, food intake disorder, and a poorer prognosis. Appropriate animal models need to be developed for a better understanding of the mechanisms underlying the metastatic process of breast cancer cells to mandible and to test the effects of potential lead compounds. Here, we assessed the metastasis model of intracardiac injection using luciferase-transfected metastatic breast cancer cells (MDA-MB-231Luc+) by determining the incidences of metastasis, mCT images, and histopathological results. A high bioluminescence signal mainly detected mandibular lesions with less frequent distal femora and proximal tibiae lesions. Extensive mandibular bone destruction occurred in nude mice grafted with metastatic breast cancer cells. This type of animal model might be a useful tool in assessing therapeutic implications and the efficacy of anti-cancer drugs for osteolytic cancers.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141749
DOI
10.1590/1678-775720140158
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral and Maxillofacial Radiology
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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