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Serum Reactivity Against Herpes Simplex Virus Type 1 UL48 Protein in Behçet's Disease Patients and a Behçet's Disease-like Mouse Model

Authors
 Zhenlong Zheng ; Seonghyang Sohn ; Sung Bin Cho ; Dongsik Bang ; Keun Jae Ahn 
Citation
 Acta Dermato-Venereologica, Vol.95(8) : 952~958, 2015 
Journal Title
 Acta Dermato-Venereologica 
ISSN
 0001-5555 
Issue Date
2015
Abstract
Herpes simplex virus (HSV) infection is a possible pathogenic factor in Behçet's disease (BD). Using proteomics analysis, this study detected a target HSV protein. Serum IgA and IgG reactivities against the identified protein were evaluated in patients with BD and in BD-like mice. A total of 4 protein bands generated by immunoprecipitation were analysed by proteomics, and HSV UL48 was commonly found in both IgA- and IgG-reactive protein bands. Compared with controls, patients with BD and BD-like mice exhibited higher titres of IgA reacting with recombinant HSV UL48 protein. Further proteomics analysis revealed that human heat shock cognate 71 kDa protein (Hsc71) is a cross-reacting target antigen against anti-HSV UL48 antibody. In addition, our data demonstrated a very strong association between serum IgG reactivity against recombinant human Hsc71 and recombinant HSV UL48 in patients with BD. We suggest that HSV infection and impaired human Hsc71 activity may be associated with the activation of autoreactive lymphocytes.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141741
DOI
10.2340/00015555-2127
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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