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Effect of High-Dose Statin Therapy on Drug-Eluting Stent Strut Coverage

Title
Effect of High-Dose Statin Therapy on Drug-Eluting Stent Strut Coverage
Authors
Jung-Sun Kim;Jeong Hun Kim;Myeong-Ki Hong;Yangsoo Jang;Donghoon Choi;Young-Guk Ko;Byeong-Keuk Kim;Dong-Ho Shin
Issue Date
2015
Journal Title
Arteriosclerosis Thromobosis and Vascular Biology
ISSN
1079-5642
Citation
Arteriosclerosis Thromobosis and Vascular Biology, Vol.35(11) : 2460~2467, 2015
Abstract
OBJECTIVE: The influence of high-dose statin therapy on the serial stent healing process has not been fully investigated. Using optical coherence tomography, the effect of high-dose statin therapy on stent strut coverage was evaluated in drug-eluting stent-treated patients. APPROACH AND RESULTS: Sixty patients were randomly assigned to 2 groups according to the statin dose (atorvastatin 40 mg as high-dose statin therapy [n=29] versus pravastatin 20 mg as low-dose statin therapy [n=31]). Serial optical coherence tomographic evaluation post procedure and at the 3-month and 12-month follow-ups was performed in 50 patients with 54 stents (23 atorvastatin-treated patients versus 27 pravastatin-treated patients). The percentage of uncovered struts was defined as the ratio of uncovered struts/total struts. The primary end point was the percentage of uncovered struts at the 12-month follow-up. The secondary end point was the percentage of uncovered struts at the 3-month follow-up and the comparative percentage change (Δ) of uncovered struts at the 3- and 12-month follow-ups between the different dose statin therapies. The percentage of uncovered struts was 7.4% (range, 4.3%-10.4%) in atorvastatin-treated patients versus 10.6% (range, 5.7%-22.6%) in pravastatin-treated patients at the 3-month follow-up (P=0.13) and 1.3% (0.3%-3.8%) versus 2.5% (0.9%-9.7%), respectively, at the 12-month follow-up (P=0.01). The percentage Δ of uncovered struts from 3 to 12 months of follow-up was -7.9±8.5% in atorvastatin-treated patients versus -9.3±12.5% in pravastatin-treated patients (P=0.67). CONCLUSIONS: This study suggested that high-dose statin therapy might provide a beneficial effect for the vascular healing process after drug-eluting stent implantation.
URI
http://atvb.ahajournals.org/content/35/11/2460.long

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141736
DOI
10.1161/ATVBAHA.115.306037
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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