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Postural vital capacity difference with aging in duchenne muscular dystrophy

Title
 Postural vital capacity difference with aging in duchenne muscular dystrophy
Authors
 Yu Hui Won; Won Ah Choi; Seong-Woong Kang; Dong Hyun Kim
Issue Date
2015
Journal Title
 Muscle & Nerve
ISSN
 0148-639X
Citation
 Muscle & Nerve, Vol.52(5) : 722~727, 2015
Abstract
INTRODUCTION: A change in vital capacity (VC) from standing to supine can be an index of diaphragm paralysis if it exceeds 25%. We aimed to verify whether the postural VC difference increases with age and reflects diaphragm weakness in DMD. METHODS: VCs were measured in DMD. Postural VC difference and percentage were calculated from the VC data. Maximal inspiratory pressure (MIP) and MIP percentage were measured as an indirect index of diaphragm weakness. RESULTS: A total of 220 patients and 544 measurements were collected. MIP and MIP percentage decreased significantly with age (P < 0.001 for both). Estimated postural VC difference and percentage also decreased (P < 0.001, P = 0.006, respectively). Age group comparisons showed a significant decrease in younger, but not older subjects. CONCLUSIONS: This study shows that the postural VC difference tended to decrease with age and might not reflect diaphragmatic weakness in DMD; however, this should be interpreted cautiously.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141678
DOI
10.1002/mus.24623
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Rehabilitation Medicine
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/mus.24623/abstract
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