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Postural vital capacity difference with aging in duchenne muscular dystrophy

Authors
 Yu Hui Won  ;  Won Ah Choi  ;  Dong Hyun Kim  ;  Seong-Woong Kang 
Citation
 MUSCLE & NERVE, Vol.52(5) : 722-727, 2015 
Journal Title
MUSCLE & NERVE
ISSN
 0148-639X 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aging/pathology* ; Aging/physiology* ; Child ; Follow-Up Studies ; Humans ; Inspiratory Capacity/physiology ; Male ; Muscular Dystrophy, Duchenne/diagnosis* ; Muscular Dystrophy, Duchenne/physiopathology* ; Posture/physiology* ; Respiratory Muscles/pathology ; Respiratory Muscles/physiopathology ; Retrospective Studies ; Vital Capacity/physiology* ; Young Adult
Keywords
Duchenne muscular dystrophy ; age ; diaphragm ; maximal inspiratory pressure ; postural vital capacity difference
Abstract
INTRODUCTION: A change in vital capacity (VC) from standing to supine can be an index of diaphragm paralysis if it exceeds 25%. We aimed to verify whether the postural VC difference increases with age and reflects diaphragm weakness in DMD.

METHODS: VCs were measured in DMD. Postural VC difference and percentage were calculated from the VC data. Maximal inspiratory pressure (MIP) and MIP percentage were measured as an indirect index of diaphragm weakness.

RESULTS: A total of 220 patients and 544 measurements were collected. MIP and MIP percentage decreased significantly with age (P < 0.001 for both). Estimated postural VC difference and percentage also decreased (P < 0.001, P = 0.006, respectively). Age group comparisons showed a significant decrease in younger, but not older subjects.

CONCLUSIONS: This study shows that the postural VC difference tended to decrease with age and might not reflect diaphragmatic weakness in DMD; however, this should be interpreted cautiously.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mus.24623/abstract
DOI
10.1002/mus.24623
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seong Woong(강성웅) ORCID logo https://orcid.org/0000-0002-7279-3893
Choi, Won Ah(최원아) ORCID logo https://orcid.org/0000-0003-0403-8869
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/141678
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