Definitions and outcome measures for mucous membrane pemphigoid: recommendations of an international panel of experts
Dedee F. Murrell ; Branka Marinovic ; Leena Bruckner-Tuderman ; Philippe Bernard ; Valeria Aoki ; John Zone ; David Woodley ; M. Peter Marinkovich ; Marcel F. Jonkman ; David Fivenson ; Janet A. Fairley ; Donna Culton ; Luca Borradori ; Stefan Beissert ; Johann Bauer ; Masayuki Amagai ; Katarzyna Wozniak ; Razzaque Ahmed ; Catherine Prost ; Frederic Caux
Journal of the American Academy of Dermatology, Vol.72(1) : 168~174, 2015
Journal of the American Academy of Dermatology
Mucous membrane pemphigoid encompasses a group of autoimmune bullous diseases with a similar phenotype characterized by subepithelial blisters, erosions, and scarring of mucous membranes, skin, or both. Although knowledge about autoimmune bullous disease is increasing, there is often a lack of clear definitions of disease, outcome measures, and therapeutic end points. With clearer definitions and outcome measures, it is possible to directly compare the results and data from various studies using meta-analyses. This consensus statement provides accurate and reproducible definitions for disease extent, activity, outcome measures, end points, and therapeutic response for mucous membrane pemphigoid and proposes a disease extent score, the Mucous Membrane Pemphigoid Disease Area Index.