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Impact of Coronary Plaque Characteristics on Late Stent Malapposition after Drug-Eluting Stent Implantation.

Title
 Impact of Coronary Plaque Characteristics on Late Stent Malapposition after Drug-Eluting Stent Implantation.
Authors
 Sung-Jin Hong; Byeong-Keuk Kim; Myeong-Ki Hong; Yangsoo Jang; Donghoon Choi; Young-Guk Ko; Jung-Sun Kim; Dong-Ho Shin
Issue Date
2015
Journal Title
 Yonsei Medical Journal
ISSN
 0513-5796
Citation
 Yonsei Medical Journal, Vol.56(6) : 1538~1544, 2015
Abstract
PURPOSE: To evaluate the impact of pre-procedural coronary plaque composition assessed by virtual histology intravascular ultrasound (VH-IVUS) on late stent malapposition assessed by optical coherence tomography (OCT) following drug-eluting stent (DES) implantation. MATERIALS AND METHODS: The study population consisted of 121 patients (121 lesions) who underwent both pre-procedural VH-IVUS and follow-up OCT after DES implantation. The association between pre-procedural plaque composition [necrotic core (NC), dense calcium (DC), fibrotic (FT), and fibro-fatty (FF) volumes] assessed by VH-IVUS and late stent malapposition (percent malapposed struts) or strut coverage (percent uncovered struts) assessed by follow-up OCT was evaluated. RESULTS: Pre-procedural absolute total NC, DC, FT, and FF plaque volumes were 22.9±19.0, 7.9±9.6, 63.8±33.8, and 16.5±12.4 mm³, respectively. At 6.3±3.1 months post-intervention, percent malapposed and uncovered struts were 0.8±2.5% and 15.3±16.7%, respectively. Pre-procedural absolute total NC and DC plaque volumes were positively correlated with percent malapposed struts (r=0.44, p<0.001 and r=0.45, p<0.001, respectively), while pre-procedural absolute total FT plaque volume was weakly associated with percent malapposed struts (r=0.220, p=0.015). Pre-procedural absolute total DC plaque volume was the only independent predictor of late stent malapposition on multivariate analysis (β=1.12, p=0.002). There were no significant correlations between pre-intervention plaque composition and percent uncovered struts. CONCLUSION: Pre-procedural plaque composition was associated with late stent malapposition but not strut coverage after DES implantation. Larger pre-procedural absolute total DC plaque volumes were associated with greater late stent malapposition.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141482
DOI
10.3349/ymj.2015.56.6.1538.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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