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Clinicopathological features and prognostic significance of HER2 expression in gastric cancer.

Title
 Clinicopathological features and prognostic significance of HER2 expression in gastric cancer. 
Authors
 Park J.S. ; Rha S.Y. ; Kim H.S. ; Noh S.H. ; Hyung W.J. ; Cheong J.-H. ; Kim H.-I. ; An J.Y. ; Kim H. ; Jun H.J. ; Kim K.H. ; Jung M. ; Chung H.C. 
Issue Date
2015
Journal Title
 Oncology 
ISSN
 0030-2414 
Citation
 Oncology, Vol.88(3) : 147~156, 2015 
Abstract
BACKGROUND: HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS: A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included in this study. RESULTS: Ninety-five (11.7%) patients had HER2-positive gastric cancer. Elevated serum carcinoembryonic antigen (CEA) concentration [odds ratio (OR), 5.629; p < 0.001] and differentiated histology (OR, 3.717; p = 0.002) were significant predictive factors for HER2 positivity in localized disease. For recurrent or metastatic disease, elevated serum CEA concentration (OR, 2.545; p < 0.001), differentiated histology (OR, 3.299; p < 0.001), pulmonary metastasis (OR, 3.321; p = 0.001), and distant lymph node metastasis (OR, 2.286; p = 0.002) were significant predictive factors. Median disease-free survival (DFS) was shorter in HER2-positive patients than in others, especially in stage I or II disease (24.7 vs. 49.2 months; p < 0.001). Among HER2-negative patients with stage II diseases, patients who received adjuvant chemotherapy had longer DFS than others (42.2 vs. 30.7 months; p = 0.025). CONCLUSIONS: Clinicopathological factors may be useful in predicting the HER2 positivity of gastric cancer. Further studies are needed to understand the molecular basis of HER2-positive gastric cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141480
DOI
10.1159/000368555.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
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Link
 http://www.karger.com/?DOI=10.1159/000368555
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