Development of Antibiotic-intercalated Smectite Composites and Its Drug Delivery Potential in Gastric System
송윤구 ; 정동훈 ; 최우현 ; 송영구
Economic and Environmental Geology (자원환경지질), Vol.48(3) : 199~204, 2015
Economic and Environmental Geology (자원환경지질)
In this study, we aimed to make antibiotic-intercalated smectite composites using amoxicillin and clarithromycin as hygroscopic antibiotics, and gentamicin, tobramycin and netilmicin as non-hygroscopic aminoglucosides, and to check their drug delivery potential in gastric system using preliminary in-situ column release test for clarithromycinsmectite composite. All antibiotics were successfully intercalated into the interlayer of smectite by cation-exchange reaction in the batch experiment. Equilibrium batch test showed that clarithromycin-intercalation followed Langmuir isotherm and the possible maximum amount was calculated as 1.811 mmole/g. Clarithromycin was continuously released by the solutions of pH=2, 3, and 4 and the amount was decreased with pH increase.