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항생제-스멕타이트 복합물 유도 및 소화기계 약물전달체로의 가능성

Title
 항생제-스멕타이트 복합물 유도 및 소화기계 약물전달체로의 가능성 
Other Titles
 Development of Antibiotic-intercalated Smectite Composites and Its Drug Delivery Potential in Gastric System 
Authors
 송윤구 ; 정동훈 ; 최우현 ; 송영구 
Issue Date
2015
Journal Title
 Economic and Environmental Geology (자원환경지질) 
ISSN
 1225-7281 
Citation
 Economic and Environmental Geology (자원환경지질), Vol.48(3) : 199~204, 2015 
Abstract
In this study, we aimed to make antibiotic-intercalated smectite composites using amoxicillin and clarithromycin as hygroscopic antibiotics, and gentamicin, tobramycin and netilmicin as non-hygroscopic aminoglucosides, and to check their drug delivery potential in gastric system using preliminary in-situ column release test for clarithromycinsmectite composite. All antibiotics were successfully intercalated into the interlayer of smectite by cation-exchange reaction in the batch experiment. Equilibrium batch test showed that clarithromycin-intercalation followed Langmuir isotherm and the possible maximum amount was calculated as 1.811 mmole/g. Clarithromycin was continuously released by the solutions of pH=2, 3, and 4 and the amount was decreased with pH increase.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141392
DOI
10.9719/EEG.2015.48.3.199
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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