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Comparative expression of matrix metalloproteinases in internal malignancies and paired cutaneous metastatic lesions

Authors
 Kim, Tae Hyung ; Jung, Jin Young ; Roh, Mi Ryung ; Chung, Kee Yang ; Roh, Hyo Jin 
Citation
 American Journal of Dermatopathology, Vol.37(5) : 381~388, 2015 
Journal Title
 American Journal of Dermatopathology 
ISSN
 0193-1091 
Issue Date
2015
Abstract
BACKGROUND: Matrix metalloproteinase (MMP), tissue inhibitor of metalloproteinase (TIMP), and membrane-type 1 matrix metalloproteinase (MT1-MMP) are thought to be involved in the destruction of basement membrane and stromal invasion by cancer cells. OBJECTIVE: The aim of this study was to identify and compare MMP and TIMP expression in internal malignancies and paired cutaneous metastatic lesions. MATERIALS AND METHODS: We compared the expression of MMP-2, MMP-9, MT1-MMP, and TIMP-2 in the internal malignancy and paired cutaneous metastatic lesion using immunohistochemical stains. RESULTS: The cutaneous metastatic lesions expressed significantly more MMP-2, MMP-9, and MT1-MMP and significantly less TIMP-2 than did the paired internal malignancies. In breast cancer, cutaneous metastatic lesions expressed significantly more MMP-9 and significantly less TIMP-2 than did the primary breast cancer lesion. In lung cancer, the cutaneous metastatic lesion expressed significantly more MMP-2 and MT1-MMP than did the primary lesion. In stomach cancer, the cutaneous metastatic lesion expressed significantly less TIMP-2 than did the primary lesion. CONCLUSIONS: Our study demonstrates that cutaneous metastatic lesions have different MMPs and TIMP-2 expression patterns compared with their paired internal malignancies. Also, MMPs and TIMP-2 expression differs according to the type of primary cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141370
DOI
10.1097/DAD.0000000000000184
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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 http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00000372-201505000-00005&LSLINK=80&D=ovft
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