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Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease

Title
Response to Switch from Intermittent Therapy to Daily Therapy for Refractory Nodular Bronchiectatic Mycobacterium avium Complex Lung Disease
Authors
Won-Jung Koh;Byeong-Ho Jeong;Charles L. Daley;Sung Jae Shin;Nam Yong Lee;Chang-Seok Ki;Hee Jae Huh;Su-Young Kim;Hye Yun Park;Kyeongman Jeon
Issue Date
2015
Journal Title
Anti-Cancer Agents in Medicinal Chemistry
ISSN
0066-4804
Citation
Anti-Cancer Agents in Medicinal Chemistry, Vol.59(8) : 4994~4996, 2015
Abstract
Intermittent three-times-weekly antibiotic therapy is recommended for the initial treatment of patients with noncavitary nodular bronchiectatic Mycobacterium avium complex lung disease. Although some experts recommend switching from intermittent to daily therapy for patients whose sputum has persistent positive cultures after intermittent therapy, the clinical efficacy of these modifications is unknown. Of 20 patients whose sputum had persistent positive cultures after 12 months of intermittent antibiotic therapy, specimens from 6 patients (30%) achieved a negative culture after a change to daily therapy.
URI
http://aac.asm.org/content/59/8/4994.long

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141346
DOI
10.1128/AAC.00648-15
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Microbiology
Yonsei Authors
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