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Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy.

Title
 Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy. 
Authors
 Sun Young Jang ; Ka Hyun Lee ; Jin Sook Yoon ; Bo Yeon Kim ; Jong Rok Oh 
Issue Date
2015
Journal Title
 Yonsei Medical Journal 
ISSN
 0513-5796 
Citation
 Yonsei Medical Journal, Vol.56(5) : 1389~1394, 2015 
Abstract
PURPOSE: To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid. MATERIALS AND METHODS: Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy. RESULTS: Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3-120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies. CONCLUSION: TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141325
DOI
10.3349/ymj.2015.56.5.1389.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Ophthalmology
Yonsei Authors
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