The purpose of this study is to investigate the effects of 12 weeks combined exercise program on muscular strength, physical function, and flexibility in patients with Parkinson’s disease. A quasi-experimental study design was used. Thirty six patients with Parkinson’s disease were recruited and divided into either exercise group or control group. The 12-week combined exercise program included line dance as aerobic exercise and resistance exercise using their own body weight and thera band twice a week. Muscular strength was measured by a hand held dynamometer. Six minutes walk test was used to assess physical function. Sit and reach and back scratch test were conducted to measure flexibility. After the 12 week exercise program, the exercise group increased upper body and lower body muscle strength compared to the control group. In addition, physical function increased in the exercise group, while no change was observed in the control group. The change in flexibility between exercise and control group was not statistically significant. In conclusion, the 12 weeks combined exercise program improved muscular strength and physical function in patients with Parkinson’s disease.