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BRAF mutation in fine-needle aspiration specimens as a potential predictor for persistence/recurrence in patients with classical papillary thyroid carcinoma larger than 10 mm at a BRAF mutation prevalent area

Authors
 곽진영 ; 김은경 ; 문희정 ; 신동엽 ; 정웅윤 
Citation
 Head & Neck, Vol.37(10) : 1432~1438, 2015 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2015
Abstract
BACKGROUND: The association between the BRAF mutation and persistence/recurrence was investigated in patients with classical papillary thyroid carcinoma (PTC) at a BRAF mutation prevalent area. METHODS: A total of 282 patients with total thyroidectomy and prophylactic central neck dissection were included in this study. The BRAF mutation was evaluated with cytology specimen using dual priming oligonucleotide (DPO)-based multiplex polymerase chain reaction (PCR) and direct sequencing preoperatively. RESULTS: Thirty-four patients (12%) had persistence/recurrence. In all PTC, the BRAF mutation on both methods was not associated with persistence/recurrence. In PTC >10 mm, the BRAF mutation on DPO-based multiplex PCR was significantly associated with persistence/recurrence and a potential predictor for persistence/recurrence. In PTC ≤10 mm, none of the covariates were significantly different between patients with and without persistence/recurrence. CONCLUSION: The BRAF mutation was significantly associated with persistence/recurrence and a potential predictor in patients with classical PTC >10 mm at a BRAF mutation prevalent area.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141142
DOI
10.1002/hed.23770
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Radiology
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
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Link
 http://onlinelibrary.wiley.com/doi/10.1002/hed.23770/abstract
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