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Viral infections during pregnancy

Title
 Viral infections during pregnancy
Authors
 Michelle Silasi; Ingrid Cardenas; Gil Mor; Paula Aldo; Karen Racicot; Ja-Young Kwon
Issue Date
2015
Journal Title
 American Journal of Reproductive Immunology
ISSN
 1046-7408
Citation
 American Journal of Reproductive Immunology, Vol.73(3) : 199~213, 2015
Abstract
Viral infections during pregnancy have long been considered benign conditions with a few notable exceptions, such as herpes virus. The recent Ebola outbreak and other viral epidemics and pandemics show how pregnant women suffer worse outcomes (such as preterm labor and adverse fetal outcomes) than the general population and non-pregnant women. New knowledge about the ways the maternal-fetal interface and placenta interact with the maternal immune system may explain these findings. Once thought to be 'immunosuppressed', the pregnant woman actually undergoes an immunological transformation, where the immune system is necessary to promote and support the pregnancy and growing fetus. When this protection is breached, as in a viral infection, this security is weakened and infection with other microorganisms can then propagate and lead to outcomes, such as preterm labor. In this manuscript, we review the major viral infections relevant to pregnancy and offer potential mechanisms for the associated adverse pregnancy outcomes.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/141012
DOI
10.1111/aji.12355
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Obstetrics & Gynecology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/aji.12355/abstract
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