Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study

0 808

Cited 12 times in

Authors: Park K.S. ; Ryu G.W. ; Jhee J.H. ; Kim H.W. ; Park S. ; Lee S.A. ; Kwon Y.E. ; Kim Y.L. ; Ryu H.J. ; Lee M.J. ; Han S.H. ; Yoo T.-H. ; Kim Y.-L. ; Kim Y.S. ; Yang C.W. ; Kim N.-H. ; Kang S.-W. ; Park J.T.

MeSH: Aged ; Bacterial Infections/blood* ; Bacterial Infections/etiology ; Bacterial Infections/mortality ; Bacterial Infections/therapy ; Biomarkers/blood ; Cardiovascular Diseases/blood* ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/mortality ; Cardiovascular Diseases/therapy ; Female ; Ferritins/blood* ; Humans ; Inflammation ; Kidney Failure, Chronic/blood* ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/mortality ; Kidney Failure, Chronic/therapy ; Male ; Middle Aged ; Nutritional Status ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Renal Dialysis* ; Risk Factors

Keywords: Clinical outcome ; End-stage renal disease ; Ferritin ; Hemodialysis

Abstract: BACKGROUND: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated.

METHODS: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations.

RESULTS: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003).

CONCLUSION: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

Yonsei Authors: Kang, Shin Wook(강신욱) https://orcid.org/0000-0002-5677-4756
Kwon, Young Eun(권영은)
Kim, Yung Ly(김영리)
Kim, Hyung Woo(김형우) https://orcid.org/0000-0002-6305-452X
Ryu, Geun Woo(류근우)
Ryu, Han Jak(류한작)
Park, Kyoung Sook(박경숙)
Park, Seo Hyun(박서현)
Park, Jung Tak(박정탁) https://orcid.org/0000-0002-2325-8982
Yoo, Tae Hyun(유태현) https://orcid.org/0000-0002-9183-4507
Lee, Mi Jung(이미정)
Lee, Sul A(이슬아)
Jhee, Jong Hyun(지종현)
Han, Seung Hyeok(한승혁) https://orcid.org/0000-0001-7923-5635

Show full item record Find it @ YMLIB

YUHSpace: Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study