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Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study

Title
Serum Ferritin Predicts Mortality Regardless of Inflammatory and Nutritional Status in Patients Starting Dialysis: A Prospective Cohort Study
Authors
Park K.S.;Ryu G.W.;Park J.T.;Kang S.-W.;Kim N.-H.;Yang C.W.;Kim Y.S.;Kim Y.-L.;Yoo T.-H.;Han S.H.;Lee M.J.;Ryu H.J.;Kim Y.L.;Kwon Y.E.;Lee S.A.;Park S.;Kim H.W.;Jhee J.H.
Issue Date
2015
Journal Title
Blood Purification
ISSN
0253-5068
Citation
Blood Purification, Vol.40(3) : 209~217, 2015
Abstract
BACKGROUND: The impact of serum ferritin on prognosis in patients starting hemodialysis (HD) is not fully elucidated. METHODS: A prospective cohort of 946 incident HD patients from 26 dialysis centers in Korea was selected for this study. Patients were divided into tertiles according to natural logarithm (Ln) ferritin concentrations. RESULTS: During a median follow-up of 39 months, 88 (9.3%) patients died. Multivariate Cox proportional hazard analysis demonstrated that Ln ferritin was independently associated with an increase in cardiovascular mortality risk (hazard ratio (HR) 1.604, 95% CI 1.040-2.474, p = 0.033), infection-related mortality risk (HR 1.916, 95% CI 1.056-3.476, p = 0.032), and all-cause mortality risk (HR 1.547, 95% CI 1.156-2.069, p = 0.003). CONCLUSION: Serum ferritin levels at the time of HD commencement were a significant independent risk factor for mortality regardless of systemic inflammation and nutritional status. Therefore, elevated serum ferritin levels could be an effective indicator for prognosis.
URI
http://www.karger.com/Article/FullText/438819

http://ir.ymlib.yonsei.ac.kr/handle/22282913/141001
DOI
10.1159/000438819
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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