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소아천식에서 천식 조절 상태 평가 도구의 유용성

Title
 소아천식에서 천식 조절 상태 평가 도구의 유용성
Other Titles
 Utility of tools for the assessment of asthma control in childhood asthma
Authors
 김환수; 김윤희; 김규언; 손명현; 김경원; 박영아; 한윤기; 이희선
Issue Date
2015
Journal Title
 Allergy Asthma & Respiratory Disease (소아알레르기 호흡기학회지)
ISSN
 2288-0402
Citation
 Allergy Asthma & Respiratory Disease (소아알레르기 호흡기학회지), Vol.3(4) : 261~266, 2015
Abstract
Purpose : The goal of asthma control is to maintain well-controlled state. In this study, we investigated whether childhood asthma control test (C-ACT) may reflect lung function and whether fractional exhaled nitric oxide (FeNO) can be used to improve the accuracy of C-ACT in reflecting the asthma control level. Methods : We reviewed the medical records of 155 patients with asthma underwent lung function tests and C-ACT upon visiting our outpatient clinic. We compared lung function test results according to the C-ACT score stratified by atopy and also examined FeNO according to C-ACT and the Global Initiative for Asthma (GINA) guidelines. The diagnostic accuracy of well-controlled asthma by C-ACT, FeNO, and C-ACT+FeNO was examined. We also calculated the cutoff value of FeNO and C-ACT for well-controlled asthma. Results : Peak expiratory flow (PEF) showed a significant correlation with the C-ACT score. Stratified by atopy, PEF, and forced expiration in one second (FEV1) showed significant correlations with the C-ACT score in the atopic asthma group. There was no difference in FeNO between subjects with C-ACT≥20 and <20, but FeNO was significantly higher in the uncontrolled asthma according to the GINA guidelines. The diagnostic accuracy of well-controlled asthma was higher when FeNO was combined with the C-ACT score than C-ACT or FeNO. Our study showed that the cutoff values of C-ACT and FeNO 19 and 18.3 ppb (parts per billion), respectively, for well-controlled asthma. Conclusion : C-ACT showed a significant correlation with PEF, and atopic asthma group showed significant correlations with PEF and FEV1. A combination of C-ACT with FeNO might reflect asthma control status more accurately.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140866
DOI
10.4168/aard.2015.3.4.261
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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