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소아천식에서 천식 조절 상태 평가 도구의 유용성

Other Titles
 Utility of tools for the assessment of asthma control in childhood asthma 
Authors
 김환수 ; 김윤희 ; 김규언 ; 손명현 ; 김경원 ; 박영아 ; 한윤기 ; 이희선 
Citation
 Allergy Asthma & Respiratory Disease (소아알레르기 호흡기학회지), Vol.3(4) : 261~266, 2015 
Journal Title
 Allergy Asthma & Respiratory Disease (소아알레르기 호흡기학회지) 
ISSN
 2288-0402 
Issue Date
2015
Abstract
Purpose : The goal of asthma control is to maintain well-controlled state. In this study, we investigated whether childhood asthma control test (C-ACT) may reflect lung function and whether fractional exhaled nitric oxide (FeNO) can be used to improve the accuracy of C-ACT in reflecting the asthma control level. Methods : We reviewed the medical records of 155 patients with asthma underwent lung function tests and C-ACT upon visiting our outpatient clinic. We compared lung function test results according to the C-ACT score stratified by atopy and also examined FeNO according to C-ACT and the Global Initiative for Asthma (GINA) guidelines. The diagnostic accuracy of well-controlled asthma by C-ACT, FeNO, and C-ACT+FeNO was examined. We also calculated the cutoff value of FeNO and C-ACT for well-controlled asthma. Results : Peak expiratory flow (PEF) showed a significant correlation with the C-ACT score. Stratified by atopy, PEF, and forced expiration in one second (FEV1) showed significant correlations with the C-ACT score in the atopic asthma group. There was no difference in FeNO between subjects with C-ACT≥20 and <20, but FeNO was significantly higher in the uncontrolled asthma according to the GINA guidelines. The diagnostic accuracy of well-controlled asthma was higher when FeNO was combined with the C-ACT score than C-ACT or FeNO. Our study showed that the cutoff values of C-ACT and FeNO 19 and 18.3 ppb (parts per billion), respectively, for well-controlled asthma. Conclusion : C-ACT showed a significant correlation with PEF, and atopic asthma group showed significant correlations with PEF and FEV1. A combination of C-ACT with FeNO might reflect asthma control status more accurately.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140866
DOI
10.4168/aard.2015.3.4.261
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Pediatrics
Yonsei Authors
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