Cited 0 times in

Circadian Oscillation of Sulfiredoxin in the Mitochondria

Title
 Circadian Oscillation of Sulfiredoxin in the Mitochondria 
Authors
 In Sup Kil ; Keun Woo Ryu ; Sue Goo Rhee ; Sunjoo Park ; Ju Hee Kim ; Sei Yoon Chu ; Jeong Yeon Kim ; Se Kyoung Lee 
Issue Date
2015
Journal Title
 Molecular Cell 
ISSN
 1097-2765 
Citation
 Molecular Cell, Vol.59(4) : 651~663, 2015 
Abstract
Hydrogen peroxide (H2O2) released from mitochondria regulates various cell signaling pathways. Given that H2O2-eliminating enzymes such as peroxiredoxin III (PrxIII) are abundant in mitochondria, however, it has remained unknown how such release can occur. Active PrxIII-SH undergoes reversible inactivation via hyperoxidation to PrxIII-SO2, which is then reduced by sulfiredoxin. We now show that the amounts of PrxIII-SO2 and sulfiredoxin undergo antiphasic circadian oscillation in the mitochondria of specific tissues of mice maintained under normal conditions. Cytosolic sulfiredoxin was found to be imported into the mitochondria via a mechanism that requires formation of a disulfide-linked complex with heat shock protein 90, which is promoted by H2O2 released from mitochondria. The imported sulfiredoxin is degraded by Lon in a manner dependent on PrxIII hyperoxidation state. The coordinated import and degradation of sulfiredoxin provide the basis for sulfiredoxin oscillation and consequent PrxIII-SO2 oscillation in mitochondria and likely result in an oscillatory H2O2 release.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140859
DOI
10.1016/j.molcel.2015.06.031
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
Yonsei Authors
사서에게 알리기
  feedback
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse