Cited 0 times in

Low Serum Bicarbonate Predicts Residual Renal Function Loss in Peritoneal Dialysis Patients

Title
Low Serum Bicarbonate Predicts Residual Renal Function Loss in Peritoneal Dialysis Patients
Authors
Tae Ik Chang;Ea Wha Kang;Seung Hyeok Han;Dae Suk Han;Kyu Hun Choi;Shin-Wook Kang;Sug Kyun Shin;Tae-Hyun Yoo;Jung Tak Park;Cheol Ho Park;Geun Woo Ryu;Hyung Woo Kim
Issue Date
2015
Journal Title
Medicine
ISSN
0025-7974
Citation
Medicine, Vol.94(31) : e1276, 2015
Abstract
Low residual renal function (RRF) and serum bicarbonate are associated with adverse outcomes in peritoneal dialysis (PD) patients. However, a relationship between the 2 has not yet been determined in these patients. Therefore, this study aimed to investigate whether low serum bicarbonate has a deteriorating effect on RRF in PD patients.This prospective observational study included a total of 405 incident patients who started PD between January 2000 and December 2005. We determined risk factors for complete loss of RRF using competing risk methods and evaluated the effects of time-averaged serum bicarbonate (TA-Bic) on the decline of RRF over the first 3 years of dialysis treatment using generalized linear mixed models.During the first 3 years of dialysis, 95 (23.5%) patients became anuric. The mean time until patients became anuric was 20.8 ± 9.0 months. After adjusting for multiple potentially confounding covariates, an increase in TA-Bic level was associated with a significantly decreased risk of loss of RRF (hazard ratio per 1 mEq/L increase, 0.84; 0.75-0.93; P = 0.002), and in comparison to TA-Bic ≥ 24 mEq/L, TA-Bic < 24 mEq/L conferred a 2.62-fold higher risk of becoming anuric. Furthermore, the rate of RRF decline estimated by generalized linear mixed models was significantly greater in patients with TA-Bic < 24 mEq/L compared with those with TA-Bic ≥ 24 mEq/L (-0.16 vs -0.11 mL/min/mo/1.73 m, P < 0.001).In this study, a clear association was found between low serum bicarbonate and loss of RRF in PD patients. Nevertheless, whether correction of metabolic acidosis for this indication provides additional protection for preserving RRF in these patients is unknown. Future interventional studies should more appropriately address this question.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/140828
DOI
10.1097/MD.0000000000001276
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
사서에게 알리기
  feedback
Files in This Item:
T201502973.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse