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Gastrin-releasing peptide expression and its effect on the calcification of developing mouse incisor

Authors
 Dong-Joon Lee ; Chengri Jin ; Han-Sung Jung ; Jong-Min Lee ; Eun-Jung Kim 
Citation
 Histochemistry and Cell Biology, Vol.144(3) : 273~279, 2015 
Journal Title
 Histochemistry and Cell Biology 
ISSN
 0948-6143 
Issue Date
2015
Abstract
Gastrin-releasing peptide (GRP) is considered to be one of the cancer growth factors. This peptide's receptor (GRPR) is known as a G protein-coupled receptor, regulating intracellular calcium storage and releasing signals. This study is the first to investigate the function of GRP during mouse incisor development. We hypothesized that GRP is one of the factors that affects the regulation of calcification during tooth development. To verify the expression pattern of GRP, in situ hybridization was processed during incisor development. GRP was expressed at the late bell stage and hard tissue formation stage in the epithelial tissue. To identify the genuine function of GRP during incisor development, a gain-of-function analysis was performed. After GRP overexpression in culture, the phenotype of ameloblasts, odontoblasts and predentin was altered compared to control group. Moreover, enamel and dentin thickness was increased after renal capsule transplantation of GRP-overexpressed incisors. With these results, we suggest that GRP plays a significant role in the formation of enamel and dentin by regulating ameloblasts and predentin formation, respectively. Thus, GRP signaling is strongly related to calcium acquisition and secretion during mouse incisor development.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140827
DOI
10.1007/s00418-015-1335-1
Appears in Collections:
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00418-015-1335-1
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