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The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis

Title
The different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
Authors
Kyung Ho Pak;Ara Jo;Jae-Ho Cheong;Hyunki Kim;Younghee Choi;Hye Ji Choi
Issue Date
2015
Journal Title
BMC Cancer
ISSN
1471-2407
Citation
BMC Cancer, Vol.15(null) : 498, 2015
Abstract
BACKGROUND: Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD) has been controversial in gastric cancer. The purpose of this study was to investigate the differences of clinicopathologic characteristics with respect to I-LVD and P-LVD in gastric cancer. METHODS: Samples of I-LVD and P-LVD from 66 patients who had undergone radical gastrectomy for gastric cancer were assessed after staining with D2-40, an immunostaining marker for lymphatic endothelium. The mean number of lymphatic vessels in three hotspots was calculated in intratumoral and peritumoral areas. RESULTS: The peritumoral lymphatics were enlarged with dilated lumens compared to the intratumoral lymphatics. I-LVD was positively correlated with diffuse gastric cancer subtype, tumor stage, lymphovascular invasion, tumor node metastasis stage, and overall survival (P < 0.05). P-LVD was associated with lymphovascular invasion, node stage, and disease-free survival (P < 0.05). CONCLUSIONS: We conclude that P-LVD had an important role in lymph node metastasis, while I-LVD was more associated with depth of tumor invasion. However, both LVDs contributed to gastric cancer progression and prognosis.
URI

http://ir.ymlib.yonsei.ac.kr/handle/22282913/140801
DOI
10.1186/s12885-015-1501-9
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
1. 연구논문 > 1. College of Medicine > Dept. of Pathology
Yonsei Authors
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