Cited 20 times in
Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.date.accessioned | 2016-02-04T11:33:49Z | - |
dc.date.available | 2016-02-04T11:33:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0002-9440 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140704 | - |
dc.description.abstract | Doublecortin-like kinase 1 (Dclk1) is considered a reliable marker for tuft cells in the gastrointestinal tract. We investigated the dynamic changes of tuft cells associated with mouse models of oxyntic atrophy and metaplasia in the stomach. Increases in the numbers of Dclk1-positive tuft cells were observed in several models of parietal cell loss. However, the expanded population of Dclk1-expressing cells showed a morphologically distinct structure in apical microvilli and acetylated microtubules, which was not seen in the tuft cells present in the normal gastric mucosa. These microvillar sensory cells (MVSCs) showed no evidence of proliferation. The expansion of the MVSCs induced by oxyntic atrophy was reversible after the return of parietal cells. More important, expansion of MVSCs after induced parietal cell loss was not observed in Gast(-/-) mice. Although the Dclk1-expressing cells in the normal gastric mucosa were in part derived from Lrig1-expressing stem cells, the Lrig1-lineaged cells did not produce the expanded Dclk1-expressing cells associated with oxyntic atrophy. These studies indicate that loss of parietal cells leads to the reversible emergence of a novel Dclk1-expressing sensory cell population in the gastric mucosa. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2219~2231 | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Atrophy/metabolism | - |
dc.subject.MESH | Atrophy/pathology | - |
dc.subject.MESH | Gastric Mucosa/metabolism* | - |
dc.subject.MESH | Gastric Mucosa/pathology | - |
dc.subject.MESH | Gastrins/metabolism* | - |
dc.subject.MESH | Metaplasia | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Parietal Cells, Gastric/metabolism* | - |
dc.subject.MESH | Parietal Cells, Gastric/pathology | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/genetics | - |
dc.subject.MESH | Protein-Serine-Threonine Kinases/metabolism* | - |
dc.subject.MESH | Stomach/metabolism* | - |
dc.subject.MESH | Stomach/pathology | - |
dc.title | Dynamic expansion of gastric mucosal doublecortin-like kinase 1-expressing cells in response to parietal cell loss is regulated by gastrin | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Eunyoung Choi | - |
dc.contributor.googleauthor | Christine P. Petersen | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | James R. Goldenring | - |
dc.contributor.googleauthor | Victoria G. Weis | - |
dc.contributor.googleauthor | Janice A. Williams | - |
dc.contributor.googleauthor | Lynne A. Lapierre | - |
dc.identifier.doi | 10.1016/j.ajpath.2015.04.009 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J00100 | - |
dc.identifier.eissn | 1525-2191 | - |
dc.identifier.pmid | 26073039 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0002944015002679 | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.affiliatedAuthor | Nam, Ki Taek | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 185 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2219 | - |
dc.citation.endPage | 2231 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF PATHOLOGY, Vol.185(8) : 2219-2231, 2015 | - |
dc.identifier.rimsid | 30256 | - |
dc.type.rims | ART | - |
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