Novel methods for clinical risk stratification in patients with colorectal liver metastases
Ki-Yeol Kim ; Nam Kyu Kim ; Sang Joon Shin ; Jae Kyung Roh ; Hyuk Hur ; Byung Soh Min ; Seung Hyuk Baik ; Kang Young Lee ; Joon Suk Lim ; Gi-Hong Choi ; Jin Sub Choi ; Joong Bae Ahn ; In-Ho Cha
Cancer Research and Treatment, Vol.47(2) : 242~250, 2015
Cancer Research and Treatment
PURPOSE: Colorectal cancer patients with liver-confined metastases are classified as stage IV, but their prognoses can differ from metastases at other sites. In this study, we suggest a novel method for risk stratification using clinically effective factors.
MATERIALS AND METHODS: Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. This analysis was based on principal component analysis (PCA).
RESULTS: The survival rate was affected by carcinoembryonic antigen (CEA) level (p < 0.001; risk ratio, 1.90), distribution of liver metastasis (p=0.014; risk ratio, 1.46), and disease-free interval (DFI; p < 0.001; risk ratio, 1.98). When patients were divided into three groups according to PCA score using significantly affected factors, they showed significantly different survival patterns (p < 0.001).
CONCLUSION: The PCA scoring system based on CEA level, distribution of liver metastasis, and DFI may be useful for preoperatively determining prognoses in order to assist in clinical decisionmaking and designing future clinical trials for CLM treatment.