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O-GlcNAc modification is essential for the regulation of autophagy in Drosophila melanogaster

Authors
 Sujin Park ; Yangsin Lee ; Jin Won Cho ; Jürgen Roth ; Jae-woo Kim ; Hyeonjin Choi ; Hanbyeol Kim ; Jin Won Pak 
Citation
 Cellular and Molecular Life Sciences, Vol.72(16) : 3173~3183, 2015 
Journal Title
 Cellular and Molecular Life Sciences 
ISSN
 1420-682X 
Issue Date
2015
Abstract
O-GlcNAcylation is a dynamic post-translational modification that takes place on ser/thr residues of nucleocytoplasmic proteins. O-GlcNAcylation regulates almost all cellular events as a nutrient sensor, a transcriptional and translational regulator, and a disease-related factor. Although the role of O-GlcNAcylation in insulin signaling and metabolism are well established, the relationship between O-GlcNAcylation and autophagy is largely unknown. Here, we manipulated O-GlcNAcylation in Drosophila and found that it regulates autophagy through Akt/dFOXO signaling. We demonstrate that O-GlcNAcylation and the levels of O-GlcNAc transferase (OGT) are increased during starvation. Furthermore, Atg proteins and autolysosomes are increased in OGT-reduced flies without fasting. Atg proteins and autophagosomes are reduced in OGT-overexpressing flies. Our results suggest that not only autophagy gene expression but also autophagic structures are regulated by OGT through Akt and dFOXO. These data imply that O-GlcNAcylation is important in modulating autophagy as well as insulin signaling in Drosophila.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140656
DOI
10.1007/s00018-015-1889-z.
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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Link
 http://link.springer.com/article/10.1007%2Fs00018-015-1889-z
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