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Diagnostic utility of interferon-gamma release assay in extrapulmonary tuberculosis

Authors
 Jung Ar Shin  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Chul Min Ahn  ;  Min Kwang Byun 
Citation
 DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, Vol.82(1) : 44-48, 2015 
Journal Title
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
ISSN
 0732-8893 
Issue Date
2015
MeSH
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Diagnostic Tests, Routine/methods* ; Female ; Humans ; Interferon-gamma Release Tests/methods* ; Male ; Middle Aged ; Retrospective Studies ; Sensitivity and Specificity ; Seoul ; Tuberculosis/diagnosis* ; Young Adult
Keywords
Diagnosis ; Interferon-gamma ; Lymphadenitis ; Pleurisy ; Tuberculosis
Abstract
Early diagnosis of extrapulmonary tuberculosis (EP-TB) is essential. However, diagnosis of EP-TB is difficult. We evaluated the diagnostic utility of an interferon-gamma release assay (IGRA) in diagnosing active EP-TB among suspected patients in Korea. We retrospectively reviewed the clinical records of all patients with suspected EP-TB at Gangnam Severance Hospital in Seoul, Korea. Of the 418 patients with suspected EP-TB, 324 had active EP-TB. The tuberculosis (TB) group had a higher percentage of positive IGRAs (70.2%, 33/47) than the non-TB group (33.3%, 3/9) (P=0.034). The IGRA sensitivity and specificity were 70.2% (63.7-74.8%) and 66.7% (32.9-90.6%), respectively. The sensitivity and specificity of IGRAs in patients with TB lymphadenitis were 81.8% (61.4-90.4%) and 80.0% (35.1-98.9%), but 38.5% (31.2-45.7%) and 50.0% (2.7-97.3%) in patients with TB pleurisy. The diagnostic performance of IGRAs may vary depending on the site of EP-TB involvement. IGRA was potentially valuable for diagnosis of active EP-TB in TB lymphadenopathy.
Full Text
http://www.sciencedirect.com/science/article/pii/S073288931500036X
DOI
10.1016/j.diagmicrobio.2015.02.002
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Ahn, Chul Min(안철민)
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/140574
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