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Epidemiology and Characteristics of Metallo-β-Lactamase-Producing Pseudomonas aeruginosa

Authors
 Duck Jin Hong ; Il Kwon Bae ; Kyungwon Lee ; Hyun-Kyung Kang ; Seok Hoon Jeong ; In-Ho Jang 
Citation
 Infection & Chemotherapy, Vol.47(2) : 81~97, 2015 
Journal Title
 Infection & Chemotherapy 
ISSN
 2093-2340 
Issue Date
2015
Abstract
Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams. There are various types of metallo-β-lactamases (MBLs) in carbapenem-resistant P. aeruginosa including Imipenemase (IMP), Verona integron-encoded metallo-β-lactamase (VIM), Sao Paulo metallo-β-lactamase (SPM), Germany imipenemase (GIM), New Delhi metallo-β-lactamase (NDM), Florence imipenemase (FIM). Each MBL gene is located on specific genetic elements including integrons, transposons, plasmids, or on the chromosome, in which they carry genes encoding determinants of resistance to carbapenems and other antibiotics, conferring multidrug resistance to P. aeruginosa. In addition, these genetic elements are transferable to other Gram-negative species, increasing the antimicrobial resistance rate and complicating the treatment of infected patients. Therefore, it is essential to understand the epidemiology, resistance mechanism, and molecular characteristics of MPPA for infection control and prevention of a possible global health crisis. Here, we highlight the characteristics of MPPA.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140565
DOI
10.3947/ic.2015.47.2.81
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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