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Reduced graphene oxide-coated hydroxyapatite composites stimulate spontaneous osteogenic differentiation of human mesenchymal stem cells

Authors
 Jong Ho Lee ; Yong Cheol Shin ; Dong-Wook Han ; Suck Won Hong ; Jong-Chul Park ; Yu-Shik Hwang ; Seok Hee Kang ; Oh Seong Jin 
Citation
 Nanoscale, Vol.7(27) : 11642~11651, 2015 
Journal Title
 Nanoscale 
ISSN
 2040-3364 
Issue Date
2015
Abstract
Human mesenchymal stem cells (hMSCs) have great potential as cell sources for bone tissue engineering and regeneration, but the control and induction of their specific differentiation into bone cells remain challenging. Graphene-based nanomaterials are considered attractive candidates for biomedical applications such as scaffolds in tissue engineering, substrates for SC differentiation and components of implantable devices, due to their biocompatible and bioactive properties. Despite the potential biomedical applications of graphene and its derivatives, only limited information is available regarding their osteogenic activity. This study concentrates upon the effects of reduced graphene oxide (rGO)-coated hydroxyapatite (HAp) composites on osteogenic differentiation of hMSCs. The average particle sizes of HAp and rGO were 1270 ± 476 nm and 438 ± 180 nm, respectively. When coated on HAp particulates, rGO synergistically enhanced spontaneous osteogenic differentiation of hMSCs, without hampering their proliferation. This result was confirmed by determining alkaline phosphatase activity and mineralization of calcium and phosphate as early and late stage markers of osteogenic differentiation. It is suggested that rGO-coated HAp composites can be effectively utilized as dental and orthopedic bone fillers since these graphene-based particulate materials have potent effects on stimulating the spontaneous differentiation of MSCs and show superior bioactivity and osteoinductive potential.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140530
DOI
10.1039/c5nr01580d
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Medical Engineering
Yonsei Authors
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Link
 http://pubs.rsc.org/en/Content/ArticleLanding/2015/NR/C5NR01580D#!divAbstract
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