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OXA-48 계열 Carbapenemase 생성 장내세균의 출현과 확산

Authors
 송원근 ; 정석훈 ; 이경원 ; 이승순 ; 이재갑 
Citation
 Korean Journal of Nosocomial Infection Control (병원감염관리), Vol.20(1) : 7~18, 2015 
Journal Title
 Korean Journal of Nosocomial Infection Control (병원감염관리) 
ISSN
 1226-2382 
Issue Date
2015
Abstract
Since 2001, ten more OXA-48 variants have been identified. Shewanella spp. has been thought to be the original host for OXA-48-like enzymes. These enzymes strongly hydrolyze penicillins and weakly hydrolyze carbapenems, with very weak activity against broad-spectrum cephalosporins. The OXA-48-like genes are always plasmid-borne and have been located in insertion sequences. OXA-48-like carbapenemases have been identified mainly from Turkey, North African countries, the Middle East, and India. Furthermore, the emergence and outbreak of OXA-48-like producers in Korea have been reported recently. Because some OXA-48-like-producing Enterobacteriaceae isolates do not exhibit resistance to broad-spectrum cephalosporins and only decreased susceptibility to carbapenems, their detection can be difficult. Adequate screening and detection methods are required to prevent and control the dissemination of OXA-48-like-producing Enterobacteriaceae.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/140488
DOI
10.14192/kjnic.2015.20.1.7
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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