Cited 3 times in
A 12-Month Single Arm Pilot Study to Evaluate the Efficacy and Safety of Sirolimus in Combination with Tacrolimus in Kidney Transplant Recipients at High Immunologic Risk
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박용정 | - |
dc.contributor.author | 이재근 | - |
dc.contributor.author | 이주한 | - |
dc.contributor.author | 허규하 | - |
dc.contributor.author | 김범석 | - |
dc.contributor.author | 김유선 | - |
dc.date.accessioned | 2016-02-04T11:19:23Z | - |
dc.date.available | 2016-02-04T11:19:23Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140167 | - |
dc.description.abstract | The optimal immunosuppressive strategy for renal transplant recipients at high immunologic risk remains a topic of investigation. This prospective single arm pilot study was undertaken to evaluate the safety and efficacy of a combined tacrolimus and sirolimus regimen in recipients at immunological high risk and to compare outcomes with a contemporaneous control group received tacrolimus and mycophenolate mofetil. Patients that received a renal allograft between 2010 and 2011 at high risk (defined as panel reactive antibodies > 50%, 4 or more human leukocyte antigen mismatches, or retransplantation) were enrolled. All patients received basiliximab induction and corticosteroids. A total of 28 recipients treated with tacrolimus and sirolimus were enrolled in this study and 69 recipients were retrospectively reviewed as a control group. The sirolimus group showed a higher, but not statistically significant, incidence of biopsy proven acute rejection and a lower glomerular filtration rate than the control group. Furthermore, sirolimus group was associated with significant increases in BKV infection (P = 0.031), dyslipidemia (P = 0.004), and lymphocele (P = 0.020). The study was terminated prematurely due to a high incidence of adverse events. A de novo tacrolimus/sirolimus combination regimen may not be an ideal choice for recipients at high immunological risk. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 682~687 | - |
dc.relation.isPartOf | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Drug Therapy, Combination/methods | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Graft Rejection/diagnosis | - |
dc.subject.MESH | Graft Rejection/etiology* | - |
dc.subject.MESH | Graft Rejection/prevention & control* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunocompromised Host | - |
dc.subject.MESH | Immunosuppressive Agents/administration & dosage | - |
dc.subject.MESH | Immunosuppressive Agents/adverse effects | - |
dc.subject.MESH | Kidney Transplantation/adverse effects* | - |
dc.subject.MESH | Longitudinal Studies | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Sirolimus/administration & dosage* | - |
dc.subject.MESH | Sirolimus/adverse effects | - |
dc.subject.MESH | Survival Rate | - |
dc.subject.MESH | Tacrolimus/administration & dosage* | - |
dc.subject.MESH | Tacrolimus/adverse effects | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | A 12-Month Single Arm Pilot Study to Evaluate the Efficacy and Safety of Sirolimus in Combination with Tacrolimus in Kidney Transplant Recipients at High Immunologic Risk | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Surgery (외과학) | - |
dc.contributor.googleauthor | Juhan Lee | - |
dc.contributor.googleauthor | Jung Jun Lee | - |
dc.contributor.googleauthor | Beom Seok Kim | - |
dc.contributor.googleauthor | Jae Geun Lee | - |
dc.contributor.googleauthor | Kyu Ha Huh | - |
dc.contributor.googleauthor | Yongjung Park | - |
dc.contributor.googleauthor | Yu Seun Kim | - |
dc.identifier.doi | 10.3346/jkms.2015.30.6.682 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01582 | - |
dc.contributor.localId | A03068 | - |
dc.contributor.localId | A03163 | - |
dc.contributor.localId | A04344 | - |
dc.contributor.localId | A00488 | - |
dc.contributor.localId | A00785 | - |
dc.relation.journalcode | J01517 | - |
dc.identifier.eissn | 1598-6357 | - |
dc.identifier.pmid | 26028917 | - |
dc.subject.keyword | Graft Rejection | - |
dc.subject.keyword | Kidney Transplantation | - |
dc.subject.keyword | Sirolimus | - |
dc.subject.keyword | Tacrolimus | - |
dc.contributor.alternativeName | Park, Yong Jung | - |
dc.contributor.alternativeName | Lee, Jae Geun | - |
dc.contributor.alternativeName | Lee, Ju Han | - |
dc.contributor.alternativeName | Huh, Kyu Ha | - |
dc.contributor.alternativeName | Kim, Beom Seok | - |
dc.contributor.alternativeName | Kim, Yu Seun | - |
dc.contributor.affiliatedAuthor | Park, Yong Jung | - |
dc.contributor.affiliatedAuthor | Lee, Jae Geun | - |
dc.contributor.affiliatedAuthor | Lee, Ju Han | - |
dc.contributor.affiliatedAuthor | Huh, Kyu Ha | - |
dc.contributor.affiliatedAuthor | Kim, Beom Seok | - |
dc.contributor.affiliatedAuthor | Kim, Yu Seun | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 30 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 682 | - |
dc.citation.endPage | 687 | - |
dc.identifier.bibliographicCitation | JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.30(6) : 682-687, 2015 | - |
dc.identifier.rimsid | 53940 | - |
dc.type.rims | ART | - |
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