Cited 49 times in
Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans
DC Field | Value | Language |
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dc.contributor.author | 김원호 | - |
dc.contributor.author | 천재희 | - |
dc.date.accessioned | 2016-02-04T11:17:37Z | - |
dc.date.available | 2016-02-04T11:17:37Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 1078-0998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/140102 | - |
dc.description.abstract | BACKGROUND: Crohn's disease (CD) is an intractable inflammatory bowel disease of unknown cause. Recent genome-wide association studies of CD in Korean and Japanese populations suggested marginal sharing of susceptibility loci between Caucasian and Asian populations. As the 7 identified loci altogether explain 5.31% of the risk for CD, the objective of this study was to identify additional CD susceptibility loci in the Korean population. METHODS: Using the ImmunoChip custom single-nucleotide polymorphism array designed for dense genotyping of 186 loci identified through GWAS, we analyzed 722 individuals with CD and 461 controls for 96,048 SNP markers in the discovery stage, followed by validation in an additional 948 affected individuals and 977 controls. RESULTS: We confirmed 6 previously reported loci in Caucasian: GPR35 at 2q37 (rs3749172; P = 5.30 × 10, odds ratio [OR] = 1.45), ZNF365 at 10q21 (rs224143; P = 2.20 × 10, OR = 1.38), ZMIZ1 at 10q22 (rs1250569; P = 3.05 × 10, OR = 1.30), NKX2-3 at 10q24 (rs4409764; P = 7.93 × 10, OR = 1.32), PTPN2 at 18p11 (rs514000; P = 9.00 × 10, OR = 1.33), and USP25 at 21q11 (rs2823256; P = 2.49 × 10, OR = 1.35), bringing the number of known CD loci (including 3 in the HLA) in Koreans to 15. The 6 additional loci increased the total genetic variance for CD risk from 5.31% to 7.27% in Koreans. CONCLUSIONS: Although the different genetic backgrounds of CD between Asian and Western countries has been well established for the major susceptibility genes, our findings of overlapping associations offer new insights into the genetic architecture of CD. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1~7 | - |
dc.relation.isPartOf | INFLAMMATORY BOWEL DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Biomarkers/analysis* | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Crohn Disease/genetics* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Genetic Loci/genetics* | - |
dc.subject.MESH | Genetic Predisposition to Disease* | - |
dc.subject.MESH | Genome-Wide Association Study | - |
dc.subject.MESH | Genotype | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Oligonucleotide Array Sequence Analysis* | - |
dc.subject.MESH | Polymorphism, Single Nucleotide/genetics* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Young Adult | - |
dc.title | Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Yang, Suk-Kyun | - |
dc.contributor.googleauthor | Hong, Myunghee | - |
dc.contributor.googleauthor | Choi, Hyunchul | - |
dc.contributor.googleauthor | Zhao, Wanting | - |
dc.contributor.googleauthor | Jung, Yusun | - |
dc.contributor.googleauthor | Haritunians, Talin | - |
dc.contributor.googleauthor | Ye, Byong Duk | - |
dc.contributor.googleauthor | Kim, Kyung-Jo | - |
dc.contributor.googleauthor | Park, Sang Hyoung | - |
dc.contributor.googleauthor | Lee, Inchul | - |
dc.contributor.googleauthor | Kim, Won Ho | - |
dc.contributor.googleauthor | Cheon, Jae Hee | - |
dc.contributor.googleauthor | Kim, Young-Ho | - |
dc.contributor.googleauthor | Jang, Byung Ik | - |
dc.contributor.googleauthor | Kim, Hyun-Soo | - |
dc.contributor.googleauthor | Choi, Jai Hyun | - |
dc.contributor.googleauthor | Koo, Ja Seol | - |
dc.contributor.googleauthor | Lee, Ji Hyun | - |
dc.contributor.googleauthor | Jung, Sung-Ae | - |
dc.contributor.googleauthor | Shin, Hyoung Doo | - |
dc.contributor.googleauthor | Kang, Daehee | - |
dc.contributor.googleauthor | Youn, Hee-Shang | - |
dc.contributor.googleauthor | Taylor, Kent D. | - |
dc.contributor.googleauthor | Rotter, Jerome I. | - |
dc.contributor.googleauthor | Liu, Jianjun | - |
dc.contributor.googleauthor | McGovern, Dermot | - |
dc.contributor.googleauthor | Song, Kyuyoung | - |
dc.identifier.doi | 10.1097/MIB.0000000000000268 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00774 | - |
dc.contributor.localId | A04030 | - |
dc.relation.journalcode | J01060 | - |
dc.identifier.eissn | 1536-4844 | - |
dc.identifier.pmid | 25489960 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00054725-201501000-00001&LSLINK=80&D=ovft | - |
dc.subject.keyword | Crohn's disease | - |
dc.subject.keyword | genetics | - |
dc.subject.keyword | ImmunoChip | - |
dc.subject.keyword | Korean | - |
dc.contributor.alternativeName | Kim, Won Ho | - |
dc.contributor.alternativeName | Cheon, Jae Hee | - |
dc.contributor.affiliatedAuthor | Kim, Won Ho | - |
dc.contributor.affiliatedAuthor | Cheon, Jae Hee | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 7 | - |
dc.identifier.bibliographicCitation | INFLAMMATORY BOWEL DISEASES, Vol.21(1) : 1-7, 2015 | - |
dc.identifier.rimsid | 53653 | - |
dc.type.rims | ART | - |
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