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MicroRNA-29b inhibits migration and proliferation of vascular smooth muscle cells in neointimal formation

Authors
 Jiyun Lee  ;  Soyeon Lim  ;  Byeong-Wook Song  ;  Min-Ji Cha  ;  Onju Ham  ;  Se-Yeon Lee  ;  Changyoun Lee  ;  Jun-Hee Park  ;  Yoonjin Bae  ;  Hyang-Hee Seo  ;  Minji Seung  ;  Eunhyun Choi  ;  Ki-Chul Hwang 
Citation
 JOURNAL OF CELLULAR BIOCHEMISTRY, Vol.116(4) : 598-608, 2015 
Journal Title
JOURNAL OF CELLULAR BIOCHEMISTRY
ISSN
 0730-2312 
Issue Date
2015
MeSH
Animals ; Carotid Artery Injuries/genetics* ; Carotid Artery Injuries/metabolism ; Cell Movement ; Cell Proliferation ; Cells, Cultured ; Disease Models, Animal ; Gene Expression Regulation ; Interleukin-3/pharmacology* ; Matrix Metalloproteinase 2/genetics ; MicroRNAs/metabolism* ; Muscle, Smooth, Vascular/cytology* ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/physiology* ; Neointima/genetics* ; Rats ; Rats, Sprague-Dawley
Keywords
MIGRATION ; MicroRNA-29b ; PROLIFERATION ; SMOOTH MUSCLE CELL
Abstract
The proliferation and migration of smooth muscle cells (SMCs) are considered to be key steps in the progression of atherosclerosis and restenosis. Certain stimuli, such as, interleukin-3 (IL-3) are known to stimulate proliferation and migration in vascular diseases. Meanwhile, microRNAs (miRs) have been revealed as critical modulators of various diseases in which miR-29b is known to regulate cell growth by targeting Mcl-1 and MMP2. However, roles of miR-29b in vascular smooth muscle cells remain almost unknown. We hypothesized that miR-29b may control the proliferation and migration processes induced by IL-3 stimulation by inhibiting its own specific targets in SMCs. MiR-29b significantly suppressed the proliferation and migration of SMCs through the inhibition of the signaling pathway related to Mcl-1 and MMP2. We also found that miR-29b expression levels significantly declined in balloon-injured rat carotid arteries and that the overexpression of miR-29b by local oligonucleotide delivery can inhibit neointimal formation. Consistent with the critical role of miR-29b in vitro, we observed down-regulated expression levels of Mcl-1 and MMP2 from the neointimal region. These results indicate that miR-29b suppressed the proliferation and migration of SMCs, possibly through the inhibition of Mcl-1 and MMP2, and suggest that miR-29b may serve as a useful therapeutic tool to treat cardiovascular diseases such as, atherosclerosis and restenosis.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jcb.25011/abstract
DOI
10.1002/jcb.25011
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Lee, Ji Yun(이지윤)
Lim, So Yeon(임소연)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/139347
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