Cited 42 times in
Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김수정 | - |
dc.contributor.author | 김유리 | - |
dc.contributor.author | 김윤덕 | - |
dc.contributor.author | 김진석 | - |
dc.contributor.author | 민유홍 | - |
dc.contributor.author | 장지은 | - |
dc.contributor.author | 정준원 | - |
dc.date.accessioned | 2016-02-04T10:56:47Z | - |
dc.date.available | 2016-02-04T10:56:47Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0939-5555 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/139328 | - |
dc.description.abstract | Early cytomegalovirus (CMV) replication (eCMV) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) has been suggested as an independent factor that reduces leukemia relapse risk. We retrospectively analyzed 74 patients with acute myeloid leukemia (AML) who underwent allo-HSCT between August 2006 and September 2012. All recipients were CMV seropositive. In 52 patients, eCMV occurred at a median of 35 days (range, 11-92) after allo-HSCT. Univariate analysis revealed that the factors associated with a reduction in the 5-year cumulative incidence of relapse (CIR) included the first complete remission status at allo-HSCT, non-adverse cytogenetics and molecular abnormalities, pre-transplant serum ferritin level <1,400 mg/dL, chronic graft-versus-host disease (cGVHD), and eCMV. In sub-group analysis, according to the existence of eCMV and cGVHD, those with both eCMV and cGVHD showed the lowest 5-year CIR (P < 0.003). Patients with both eCMV and cGVHD had the best outcome for leukemia-free survival (LFS) (P < 0.001) and OS (P < 0.001). In the CMV-seropositive population, the presence of eCMV in combination with cGVHD had a significant positive effect on LFS and OS after allo-HSCT. When eCMV preceded cGVHD, the relapse rate after allo-HSCT was significantly reduced in patients with AML. Therefore, we suggest that it is critical to have an immunological understanding of the graft-versus-leukemia effect in this setting. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 275~282 | - |
dc.relation.isPartOf | ANNALS OF HEMATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Acute Disease | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Cytomegalovirus/immunology* | - |
dc.subject.MESH | Cytomegalovirus/physiology | - |
dc.subject.MESH | Cytomegalovirus Infections/blood | - |
dc.subject.MESH | Cytomegalovirus Infections/immunology* | - |
dc.subject.MESH | Cytomegalovirus Infections/virology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Follow-Up Studies | - |
dc.subject.MESH | Graft vs Host Disease/etiology | - |
dc.subject.MESH | Graft vs Host Disease/immunology* | - |
dc.subject.MESH | Graft vs Host Disease/virology | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation/adverse effects | - |
dc.subject.MESH | Hematopoietic Stem Cell Transplantation/methods* | - |
dc.subject.MESH | Host-Pathogen Interactions/immunology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Leukemia, Myeloid/immunology* | - |
dc.subject.MESH | Leukemia, Myeloid/therapy | - |
dc.subject.MESH | Leukemia, Myeloid/virology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Recurrence, Local/immunology | - |
dc.subject.MESH | Neoplasm Recurrence, Local/virology | - |
dc.subject.MESH | Outcome Assessment (Health Care)/methods | - |
dc.subject.MESH | Outcome Assessment (Health Care)/statistics & numerical data | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Transplantation, Homologous | - |
dc.subject.MESH | Virus Replication/immunology* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Early CMV replication and subsequent chronic GVHD have a significant anti-leukemic effect after allogeneic HSCT in acute myeloid leukemia | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Eun Jang | - |
dc.contributor.googleauthor | Soo Jeong Kim | - |
dc.contributor.googleauthor | June-Won Cheong | - |
dc.contributor.googleauthor | Shin Young Hyun | - |
dc.contributor.googleauthor | Yun Deok Kim | - |
dc.contributor.googleauthor | Yu Ri Kim | - |
dc.contributor.googleauthor | Jin Seok Kim | - |
dc.contributor.googleauthor | Yoo Hong Min | - |
dc.identifier.doi | 10.1007/s00277-014-2190-1 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00633 | - |
dc.contributor.localId | A00790 | - |
dc.contributor.localId | A01017 | - |
dc.contributor.localId | A01407 | - |
dc.contributor.localId | A03477 | - |
dc.contributor.localId | A03729 | - |
dc.contributor.localId | A00779 | - |
dc.relation.journalcode | J00161 | - |
dc.identifier.eissn | 1432-0584 | - |
dc.identifier.pmid | 25135450 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00277-014-2190-1 | - |
dc.subject.keyword | Cytomegalovirus | - |
dc.subject.keyword | Chronic GVHD | - |
dc.subject.keyword | Hematopoietic stem cell transplantation | - |
dc.subject.keyword | Relapse | - |
dc.contributor.alternativeName | Kim, Soo Jeong | - |
dc.contributor.alternativeName | Kim, Yu Ri | - |
dc.contributor.alternativeName | Kim, Yun Deok | - |
dc.contributor.alternativeName | Kim, Jin Seok | - |
dc.contributor.alternativeName | Min, Yoo Hong | - |
dc.contributor.alternativeName | Jang, Ji Eun | - |
dc.contributor.alternativeName | Cheong, June Won | - |
dc.contributor.affiliatedAuthor | Kim, Soo Jeong | - |
dc.contributor.affiliatedAuthor | Kim, Yun Deok | - |
dc.contributor.affiliatedAuthor | Kim, Jin Seok | - |
dc.contributor.affiliatedAuthor | Min, Yoo Hong | - |
dc.contributor.affiliatedAuthor | Jang, Ji Eun | - |
dc.contributor.affiliatedAuthor | Cheong, June-Won | - |
dc.contributor.affiliatedAuthor | Kim, Yu Ri | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 94 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 275 | - |
dc.citation.endPage | 282 | - |
dc.identifier.bibliographicCitation | ANNALS OF HEMATOLOGY, Vol.94(2) : 275-282, 2015 | - |
dc.identifier.rimsid | 45573 | - |
dc.type.rims | ART | - |
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