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Biocompatibility and Resorption Pattern of Newly Developed Hyaluronic Acid Hydrogel Reinforced Three-layer Poly(Lactide-co-glycolide) Membrane: histologic observation in rabbit calvarial defect model

Authors
 Hoon You  ;  Eun Ung Lee  ;  You Kyoung Kim  ;  Bum Chul Kim  ;  Jin Young Park  ;  Hyun Chang Lim  ;  Jung Seok Lee  ;  InSup Noh  ;  Ui Won Jung  ;  Seong Ho Choi 
Citation
 Biomaterials Research, Vol.18 : 12, 2014 
Journal Title
Biomaterials Research
ISSN
 1226-4601 
Issue Date
2014
Keywords
Biocompatibility ; Hyaluronic acid ; Hydrogel ; Poly (lactide-co-glycolide) ; Rabbit calvaria
Abstract
BACKGROUND: The aim of this study was to evaluate the biocompatibility and resorption pattern in three-layer poly (lactide-co-glycolide) (PLGA) membrane according to the concentrations of hyaluronic acid (HA) hydrogel in rabbit calvarial defect model. Four standardized circular defects with 8 mm diameter were created on the four rabbit calvarium. Three-layer PLGA membranes (5% and 10% HA gel) were used as the test groups, both collagen membrane and monolayer PLGA membrane as the control groups.

RESULTS: After sacrificing the animals after 4 and 8 weeks, block sections were harvested and histological observation was performed. Pus formation was observed in a site on the three-layer PLGA membranes (with 10% HA gel) of 4 weeks group and initial inflammatory responses were observed on the three-layer PLGA membrane group. However, when compared to both the monolayer PLGA membrane group and collagen membrane group, the HA gel-reinforced three-layer PLGA membrane showed improved cell occlusion and retention period, showing the formation of the capsule-like structure. There was no definite difference between the results of the membranes fabricated with either 5% or 10% HA hydrogel.

CONCLUSION: The HA reinforced three-layer PGLA membrane was retained longer than control group and showed good property in cell occlusion. Future study is under process to improve the inflammatory response of the three layer PLGA membranes, which were observed in this study.
Files in This Item:
T201404879.pdf Download
DOI
10.1186/2055-7124-18-12
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jung Seok(이중석) ORCID logo https://orcid.org/0000-0003-1276-5978
Lim, Hyun Chang(임현창)
Jung, Ui Won(정의원) ORCID logo https://orcid.org/0000-0001-6371-4172
Choi, Seong Ho(최성호) ORCID logo https://orcid.org/0000-0001-6704-6124
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/138580
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