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Cortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type.

DC Field Value Language
dc.contributor.author김창수-
dc.contributor.author조재림-
dc.date.accessioned2015-12-28T11:02:22Z-
dc.date.available2015-12-28T11:02:22Z-
dc.date.issued2014-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/138561-
dc.description.abstractBACKGROUND AND PURPOSE: The progression pattern of brain structural changes in patients with isolated cerebrovascular disease (CVD) remains unclear. To investigate the role of isolated CVD in cognitive impairment patients, patterns of cortical thinning and hippocampal atrophy in pure subcortical vascular mild cognitive impairment (svMCI) and pure subcortical vascular dementia (SVaD) patients were characterized. METHODS: Forty-five patients with svMCI and 46 patients with SVaD who were negative on Pittsburgh compound B (PiB) positron emission tomography imaging and 75 individuals with normal cognition (NC) were recruited. RESULTS: Compared with NC, patients with PiB(-) svMCI exhibited frontal, language and retrieval type memory dysfunctions, which in patients with PiB(-) SVaD were further impaired and accompanied by visuospatial and recognition memory dysfunctions. Compared with NC, patients with PiB(-) svMCI exhibited cortical thinning in the frontal, perisylvian, basal temporal and posterior cingulate regions. This atrophy was more prominent and extended further toward the lateral parietal and medial temporal regions in patients with PiB(-) SVaD. Compared with NC subjects, patients with PiB(-) svMCI exhibited hippocampal shape deformities in the lateral body, whilst patients with PiB(-) SVaD exhibited additional deformities within the lateral head and inferior body. CONCLUSIONS: Our findings suggest that patients with CVD in the absence of Alzheimer's disease pathology can be demented, showing cognitive impairment in multiple domains, which is consistent with the topography of cortical thinning and hippocampal shape deformity.-
dc.description.statementOfResponsibilityopen-
dc.format.extent744~751-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAniline Compounds-
dc.subject.MESHCerebral Cortex/diagnostic imaging-
dc.subject.MESHCerebral Cortex/pathology*-
dc.subject.MESHCognitive Dysfunction/pathology*-
dc.subject.MESHDementia/pathology*-
dc.subject.MESHDementia, Vascular/diagnostic imaging-
dc.subject.MESHDementia, Vascular/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHippocampus/diagnostic imaging-
dc.subject.MESHHippocampus/pathology*-
dc.subject.MESHHumans-
dc.subject.MESHImaging, Three-Dimensional-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHThiazoles-
dc.titleCortical thickness and hippocampal shape in pure vascular mild cognitive impairment and dementia of subcortical type.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Preventive Medicine (예방의학)-
dc.contributor.googleauthorH J Kim-
dc.contributor.googleauthorB S Ye-
dc.contributor.googleauthorC W Yoon-
dc.contributor.googleauthorY Noh-
dc.contributor.googleauthorG H Kim-
dc.contributor.googleauthorH Cho-
dc.contributor.googleauthorS Jeon-
dc.contributor.googleauthorJ M Lee-
dc.contributor.googleauthorJ H Kim-
dc.contributor.googleauthorJ K Seong-
dc.contributor.googleauthorC H Kim-
dc.contributor.googleauthorY S Choe-
dc.contributor.googleauthorK H Lee-
dc.contributor.googleauthorS T Kim-
dc.contributor.googleauthorJ S Kim-
dc.contributor.googleauthorS E Park-
dc.contributor.googleauthorJ H Kim-
dc.contributor.googleauthorJ Chin-
dc.contributor.googleauthorJ Cho-
dc.contributor.googleauthorC Kim-
dc.contributor.googleauthorJ H Lee-
dc.contributor.googleauthorM W Weiner-
dc.contributor.googleauthorD L Na-
dc.contributor.googleauthorS W Seo-
dc.identifier.doi10.1111/ene.12376-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01042-
dc.contributor.localIdA03895-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid24495089-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ene.12376/abstract-
dc.subject.keywordPittsburgh compound B PET-
dc.subject.keywordcortical thickness-
dc.subject.keywordhippocampal shape-
dc.subject.keywordsubcortical vascular dementia-
dc.subject.keywordsubcortical vascular mild cognitive impairment-
dc.contributor.alternativeNameKim, Chang Soo-
dc.contributor.alternativeNameCho, Jae Lim-
dc.contributor.affiliatedAuthorKim, Chang Soo-
dc.contributor.affiliatedAuthorCho, Jae Lim-
dc.rights.accessRightsfree-
dc.citation.volume21-
dc.citation.number5-
dc.citation.startPage744-
dc.citation.endPage751-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.21(5) : 744-751, 2014-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers

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