Cited 4 times in
Antioxidant activity of caffeoyl-prolyl-histidine amide and its effects on PDGF-induced proliferation of vascular smooth muscle cells
DC Field | Value | Language |
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dc.contributor.author | 서미란 | - |
dc.contributor.author | 이은직 | - |
dc.date.accessioned | 2015-12-28T10:54:48Z | - |
dc.date.available | 2015-12-28T10:54:48Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0939-4451 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/138293 | - |
dc.description.abstract | Caffeic acid (CA) is one of the antioxidants found in plants, which protects vascular cells against vascular injuries from oxidative stress. In our previous study, caffeoyl-prolyl-histidine amide (CA-L-Pro-L-His-NH2; CA-PH; a CA derivative) was synthesized, which exhibited a strong antioxidant activity with sufficient stability. In this study, we investigated the role of CA-PH in vascular smooth muscle cells (VSMCs) and confirmed the enhanced antioxidant activity of CA-PH compared with that of CA. In in vitro tube assays, CA-PH showed a higher free-radical-scavenging activity and lipid-peroxidation-inhibition activity than those of CA. In VSMCs, CA-PH significantly reduced hydrogen peroxide-induced ROS generation and increased the expression of heme oxygenase-1. Moreover, CA-PH effectively inhibited the platelet-derived growth factor-induced cellular proliferation of VSMCs, which was confirmed by a decrease in the expression of the proliferating cell nuclear antigen and the phosphorylation of Akt. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 2777~2785 | - |
dc.relation.isPartOf | AMINO ACIDS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Amides/chemistry | - |
dc.subject.MESH | Amides/metabolism* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antioxidants/chemical synthesis | - |
dc.subject.MESH | Antioxidants/chemistry | - |
dc.subject.MESH | Antioxidants/metabolism* | - |
dc.subject.MESH | Aorta/cytology | - |
dc.subject.MESH | Aorta/metabolism | - |
dc.subject.MESH | Caffeic Acids/chemistry | - |
dc.subject.MESH | Caffeic Acids/metabolism* | - |
dc.subject.MESH | Cell Proliferation* | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Heme Oxygenase-1/genetics | - |
dc.subject.MESH | Heme Oxygenase-1/metabolism | - |
dc.subject.MESH | Histidine/chemistry | - |
dc.subject.MESH | Histidine/metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Myocytes, Smooth Muscle/cytology* | - |
dc.subject.MESH | Myocytes, Smooth Muscle/metabolism | - |
dc.subject.MESH | Oncogene Protein v-akt/genetics | - |
dc.subject.MESH | Oncogene Protein v-akt/metabolism | - |
dc.subject.MESH | Proliferating Cell Nuclear Antigen/genetics | - |
dc.subject.MESH | Proliferating Cell Nuclear Antigen/metabolism | - |
dc.subject.MESH | Proto-Oncogene Proteins c-sis/metabolism* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.title | Antioxidant activity of caffeoyl-prolyl-histidine amide and its effects on PDGF-induced proliferation of vascular smooth muscle cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seon-Yeong Kwak | - |
dc.contributor.googleauthor | Hyun Jung Lee | - |
dc.contributor.googleauthor | Jin-Kyoung Yang | - |
dc.contributor.googleauthor | Eun Jig Lee | - |
dc.contributor.googleauthor | MiRan Seo | - |
dc.contributor.googleauthor | Yoon-Sik Lee | - |
dc.identifier.doi | 10.1007/s00726-014-1834-8 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01876 | - |
dc.contributor.localId | A03050 | - |
dc.relation.journalcode | J00124 | - |
dc.identifier.eissn | 1438-2199 | - |
dc.identifier.pmid | 25218135 | - |
dc.identifier.url | http://link.springer.com/article/10.1007%2Fs00726-014-1834-8 | - |
dc.subject.keyword | Caffeoyl-prolyl-histidine amide | - |
dc.subject.keyword | Antioxidant | - |
dc.subject.keyword | Vascular smooth muscle cells | - |
dc.subject.keyword | Heme oxygenase-1 | - |
dc.contributor.alternativeName | Seo, Mi Ran | - |
dc.contributor.alternativeName | Lee, Eun Jig | - |
dc.contributor.affiliatedAuthor | Seo, Mi Ran | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jig | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 46 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 2777 | - |
dc.citation.endPage | 2785 | - |
dc.identifier.bibliographicCitation | AMINO ACIDS, Vol.46(12) : 2777-2785, 2014 | - |
dc.identifier.rimsid | 52783 | - |
dc.type.rims | ART | - |
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