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Combined treatment with human bone marrow derived mesenchymal stem cells and polymer scaffold in rat spinal cord injury
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한인보 | - |
dc.date.accessioned | 2015-12-24T09:50:11Z | - |
dc.date.available | 2015-12-24T09:50:11Z | - |
dc.date.issued | 2014 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/136685 | - |
dc.description | Dept. of Medicine/박사 | - |
dc.description.abstract | Regenerative medicine is a leading approach to treating diseases of the central nervous system. This study aimed to investigate the innate repair benefits of human mesenchymal stem cells (hMSC) coupled with the biocompatibility of a poly-lactic-co-glycolic acid (PLGA) polymer scaffold to treat a rat hemisection model of spinal cord injury. We performed thoracic segmental hemisections on Sprague-Dawley rats and treated them with either scaffolded-hMCSs, scaffold alone, hMSCs alone or saline control. This study not only confirmed the significant sensorimotor benefits of scaffoled-hMSCs after injury, but also elucidated the role of propriospinal neuron activation. The scaffolded-hMSC construct resulted in increased neuroplasticity and reduced secondary neural damage. The feasibility of autologous mesenchymal stem cell transplantation using a biodegradable polymer scaffold makes this treatment an attractive candidate for clinical investigation | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Combined treatment with human bone marrow derived mesenchymal stem cells and polymer scaffold in rat spinal cord injury | - |
dc.title.alternative | 흰쥐 척수손상 동물모델에서 인간유래 골수 중간엽 줄기세포와 고분자 지지체를 이용한 복합치료 | - |
dc.type | Thesis | - |
dc.contributor.alternativeName | Han, In Bo | - |
dc.type.local | Dissertation | - |
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