The effect of super-hydrophilie 8nm TiO2 nanotube surfaced implant on the osseointegration in mongrel dog

Abstract

In modern biomaterial and implant research, the studies on the nanostructure of TiO2 nanotube are actively being conducted due to its great surface area and good biological applicability compared to the microstructure. Because dental researchs now focus on new generation implant surface with better bioactivity and hydrophilicity, TiO2 nanotube is one of the influential candidates for next generation. In 2011, Brammer et al released a research result on the formation of 8 nm TiO2 nanotube through a new hydrothermal method different from anodization. According to the study, the created 8 nm TiO2 nanotube exhibited an excellent bioactivity with strong adhesive property and active cell function because of its super-hydrophilic nature. There are few studies about undersize 10 nm nanotube and these 8 nm TiO2 nanotube study was done in vitro study only, so it is important to carry out in vivo study. This study aimed to evaluate the impact of the surface of 8 nm TiO2 nanotube that is created through the new method on osseointegration. 20 unit 8 nm TiO2 nanotubes formed with a hydrothermal method and RBM (resorbable blasting media) implant which is widely, clinically used, was used as a control group. Under the same environment, animal tests were conducted, using 5 mongrel dogs. In 8 nm TiO2 nanotube, the removal torque value was found higher in the 12th weeks than in the 4th weeks. Bone-to-implant contact value in 8 nm TiO2 nanotube appeared to be higher than that in the control group both in the 4th and 12th week experiments. TiO2 nanotube showed higher bone volume than the control group both in the 4th and 12th week. In total bone volume, there was statistically significant difference in both groups, p-value was 0.0122. (p<0.05) Therefore, further study is required and super-hydrophilic nature and biomimetric structure should be considered very importantly in 8 nm TiO2 nanotube research, and 8 nm TiO2 nanotube is the promising candidate for new generation of implant surface.