Cited 0 times in
Adiponectin gene polymorphisms are associated with long-chain ω3 polyunsaturated fatty acids in serum phospholipids in non-diabetic Koreans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김범식 | - |
dc.date.accessioned | 2015-12-24T09:37:40Z | - |
dc.date.available | 2015-12-24T09:37:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/136187 | - |
dc.description | Dept. of Science for Aging/박사 | - |
dc.description.abstract | Objective: Hypoadiponectinemia is caused by interactions between genetic and environmental factors, including the quality of dietary fats. We investigated the association of single-nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) with dietary fat intake or fatty acid (FA) composition in serum phospholipids, plasma adiponectin, and insulin resistance (IR). Methods: Non-diabetic subjects (n=1194) were genotyped for three ADIPOQ SNPs (-11377C>G;45T>G;276G>T) after screening of eight sites. Dietary fat intake, FA composition in serum phospholipids, adiponectin, and homeostasis model assessment of IR (HOMA-IR) were also measured. Results: 276G carriers (n=1082) showed lower HDL-cholesterol (P=0.024) and adiponectin (P<0.001) but higher glucose (P=0.015) and HOMA-IR (P=0.005) than 276T/T subjects (n=112). No associations were found in other SNPs. 276G carriers showed a higher proportion of myristic acid and lower proportions of total ω6FA, total ω3FA, 18:2ω6, 20:3ω6, 20:4ω6, 18:3ω3, 20:5ω3, 22:5ω3, and 22:6ω3 in serum phospholipids. After adjusted for age, sex, BMI, and the proportion of 18:2ω6 and 18:3ω3 (biomarkers of long-term essential FA intake), 276G>T was still associated with total ω3FA (P=0.026), 20:5ω3 (P=0.021), and 22:5ω3 (P=0.024). Among FAs in serum phospholipids, 18:2ω6 highly correlated with PUFA intake (r=0.260, P<0.001) and adiponectin (r=0.150, P<0.001). 276G carriers with higher proportion of 18:2ω6 (≥12.5%) exhibited more pronounced characteristics, i.e., lower adiponectin (P<0.001), HOMA-IR (P=0.013), and long-chain ω3PUFAs (20:5ω3, 22:5ω3, and 22:6ω3, P<0.05). Additionally, the effect of 276G>T on the relationship between adiponectin and HOMA-IR was modified by 18:2ω6 proportion. Conclusion: ADIPOQ 276G is associated with reduced proportion of long-chain ω3PUFAs in serum phospholipids in non-diabetic Koreans. | - |
dc.description.statementOfResponsibility | open | - |
dc.publisher | Graduate School, Yonsei University | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Adiponectin gene polymorphisms are associated with long-chain ω3 polyunsaturated fatty acids in serum phospholipids in non-diabetic Koreans | - |
dc.title.alternative | 비당뇨 한국인에서 아디포넥틴 유전자 다형성과 혈청 인지질 중의 오메가-3 장쇄 다중불포화지방산과의 관련성 연구 | - |
dc.type | Thesis | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.alternativeName | Kim, Bum Sik | - |
dc.type.local | Dissertation | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.