Formocresol, Glutaraldehyde의 접촉시간에 따른 성견치수의 병리조직학적 연구

Abstract

[영문]

[한글]

저자는 formocresol과 glutaraldehyde를 치수치료에 사용할때 접촉시간에 따라서 치수

조직의 병리조직학적 변화를 관찰하기 위하여 생후 약1년된 성견에서 상하악 전치 및 구

치를 실험대상으로 하였다. 약제의 치수 접촉시간을 1분, 3분, 5분, 3일, 7일로 나누고

통법에 의한 치수절단술을 시행하였다. 2개월후에 실험동물을 희생시키고 표본을 고정 및

탈회한 다음 절편을 제작하고 Hematoxylin-Eosin으로 염색한 후 치수조직의 변화를 광학

현미경으로 관찰하여 다음과 같은 결론을 얻었다.

1. Formocresol 1분, 3분, 3일, 7일군과 glutaraldehyde 1분, 3일, 7일군의 치수반응은

정상 치수소견으로부터 전반적인 응고성 괴사까지 다양하게 나타났다.

2. Formocresol 5분군과 glutaraldehyde 3분, 5분군은 다른 군에 비하여 염증이 경미하

였으며 거의 정상적인 치수형태를 보였다.

3. 대부분의 formocresol군과 glutaraldehyde군에서 수복상아질이 형성되었다.

4. 상아질 흡수는 glutaraldehyde군보다 formocresol군에서 더 자주 관찰되었다.

A HISTOPATHOLOGICAL STUDY ON THE PULP TISSUE REACTI0NS TO FORMOCRESOL AND

GLUTARALDEHYDE AT THE DIFFERENT TIME INTERVALS OF APPLICATION IN DOGS

Byung Jai Choi

Department of Dental Science, Graduate School, Yonsei University

(Directed by Associate Professor, Heung Kyu Sohn, D.D.S.)

The purpose of this study is to observe the histopathological changes of the pulp

tissue after vital pulpotomy with formocresol or glutaraldehyde at the different

time intervals of application. Upper and lower teeth in seven dogs, aged about 1

years, were subjected to pulp amputations and were divided into two groups, one of

which was pulpotomized with formocresol, the other was with glutaraldehyde, The

application was performed at the intervals of 1 minute, 3 minutes, 5 minutes, 3

days and 7 days, and then the experimental animals were sacrificed 2 months after

the last experiment.

The excised jaw bones were fixed in 10% neutral buffered formalin solutions, and

they were routinely decalcified in 5% nitric acid, and embedded in paraffin, and

sections were stained with hematoxylin and eosin and observed with light

microscope.

Following results were obtained.

1. In the formocresol 1 minute-, 3 minute-, 3 day- and 7 day- groups and the

glutaraldehyde 1 minute-, 3 day- and 7 day- groups, the pulp tissue responses

varied from normal pulp tissue findings to total coagulation necrosis.

2. In the formocresol 5 minute- group and the glutaraldehyde 3 minute- and 5

minute- groups, they showed slight inflammation and the almost typical morphology

of normal pulp tissue.

3. In the almost formocresol and glutaraldehyde groups, reparative dentin was

formed.

4. Dentinal resorption in the formocresol group was more frequent than that in

the glutaraldehyde group.